Ethoxyquin

Suppliers

Names

[ CAS No. ]:
91-53-2

[ Name ]:
Ethoxyquin

[Synonym ]:
6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline
Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-
EINECS 202-075-7
6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
emq
quinoled
1,2-dihydro-2,2,4-trimethylquinolin-6-yl ethyl ether
UNII-9T1410R4OR
2,2,4-trimethyl-6-ethoxy-1,2-dihydroquinoline
nocracaw
amea100
Santoquin
usafb-24
antageaw
niflex
ETMDQ
1,2-dihydro-6-ethoxy-2,2,4-trimethylQUINOLINE
Santoflex
niflexd
MFCD00023883
Ethoxyquin

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
333.1±42.0 °C at 760 mmHg

[ Melting Point ]:
<0ºC

[ Molecular Formula ]:
C₁₄H₁₉NO

[ Molecular Weight ]:
217.307

[ Flash Point ]:
137.8±17.3 °C

[ Exact Mass ]:
217.146667

[ PSA ]:
21.26000

[ LogP ]:
3.93

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.512

[ Stability ]:
Stable. Combustible. Incompatible with oxidizing agents, strong acids. Polymerizes if heated. May polymerize upon exposure to light and air.

[ Water Solubility ]:
ethanol: 50 mL/L, clear, brown | <0.1 g/100 mL at 20 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB8225000

CHEMICAL NAME :: Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-

CAS REGISTRY NUMBER :: 91-53-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C14-H19-N-O

MOLECULAR WEIGHT :: 217.34

WISWESSER LINE NOTATION :: T66 BM CHJ C1 C1 E1 HO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1730 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14377 mg/kg/3W-C

TOXIC EFFECTS :: Blood - change in clotting factors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 gm/kg/30W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 122 gm/kg/58W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/29W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 13 gm-kg/4W (Continuous)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 99,37,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83809 No. of Facilities: 204 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 3572 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83809 No. of Facilities: 876 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 7945 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S24

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
VB8225000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Phenoxyethanamine
Acetone
4-Hydroxy-4-methyl-2-pentanone

DownStream

2-(1-Cyclohexen-1-yl)cyclohexan-1-one
6-ethoxy-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
AKOS BBS-00005656
Cyclopentanone,2-cyclopentylidene-
Quinoline,6-ethoxy-2,4-dimethyl-

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Modulation of ethoxyquin genotoxicity by free radical scavengers and DNA damage repair in human lymphocytes.

Toxicol. Lett. 193(2) , 194-9, (2010)

N-tert-butyl-alpha-phenylnitrone (PBN) and its new derivative N-(Pyridine-4-ylmethylidene)-2-carboxy-tert-butylamine N-oxide (PBNC) were synthesized and used to modulate ethoxyquin (1,2-dihydro-6-etho...

Effects of a dietary antioxidant blend and vitamin E on fatty acid profile, liver function, and inflammatory response in broiler chickens fed a diet high in oxidants.

Poult. Sci. 93(7) , 1658-66, (2014)

The aim of the current study was to determine the effects of a dietary antioxidant blend and vitamin E on fatty acid profile, inflammatory response, and liver function. Cobb 500 male broilers (n = 1,2...

Effects of a dietary antioxidant blend and vitamin E on growth performance, oxidative status, and meat quality in broiler chickens fed a diet high in oxidants.

Poult. Sci. 93(7) , 1649-57, (2014)

The aim of the study was to determine the effects of a dietary antioxidant blend (AB) and vitamin E on performance, oxidative status, and meat quality. Cobb 500 male broilers (n = 1,200, d 0) were ran...

Ethoxyquin Dimer
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1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
2-((5-(4-bromophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)thio)-N-methylacetamide
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide