6-Methylquinoline

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Names

[ CAS No. ]:
91-62-3

[ Name ]:
6-Methylquinoline

[Synonym ]:
6-Methylquinoline
p-Toluquinoline
Tolliquinoline,p
MFCD00006804
EINECS 202-084-6
6-methyl quinoline
6-Methyl-chinolin
Quinoline,6-methyl
Quinoline, 6-methyl-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
258.6±0.0 °C at 760 mmHg

[ Melting Point ]:
-22°C

[ Molecular Formula ]:
C10H9N

[ Molecular Weight ]:
143.185

[ Flash Point ]:
104.4±11.3 °C

[ Exact Mass ]:
143.073502

[ PSA ]:
12.89000

[ LogP ]:
2.54

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.625

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC0550000
CHEMICAL NAME :
Quinoline, 6-methyl-
CAS REGISTRY NUMBER :
91-62-3
BEILSTEIN REFERENCE NO. :
0110336
LAST UPDATED :
199712
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H9-N
MOLECULAR WEIGHT :
143.20
WISWESSER LINE NOTATION :
T66 BNJ H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
386 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
25 ug/plate
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A105,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R68

[ Safety Phrases ]:
S26-S36-S45-S36/37/39

[ RIDADR ]:
2810.0

[ WGK Germany ]:
3

[ RTECS ]:
VC0550000

[ Hazard Class ]:
6.1

[ HS Code ]:
29334990

Synthetic Route

Precursor & DownStream

Precursor

  • 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
  • 3-[bis(3-hydroxypropyl)amino]propan-1-ol
  • 4-Nitrotoluene
  • 6-quinolyl mesylate
  • Methylboronic acid
  • 6-methyl-1,2-dihydroquinoline
  • 3-Aminopropan-1-ol
  • 3-Dimethylaminopropanol
  • p-Toluidine

DownStream

  • 5-Amino-6-methylquinoline
  • 5-Methylindoline-2,3-dione
  • 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
  • 6-methyl-5,6,7,8-tetrahydroquinoline
  • tetrahydroquinaldine
  • 1,6-Dimethyl-2(1H)-quinolinone
  • Methyl 2-chloroquinoline-6-carboxylate
  • Quinolinic acid
  • 6-(bromomethyl)quinoline
  • 6-Quinolinecarboxaldehyde

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Chloride-sensitive fluorescent indicators.

Anal. Biochem. 293(1) , 60-6, (2001)

Three fluorescent halide-sensitive quinolinium dyes have been produced by the reaction of the 6-methylquinoline heterocyclic nitrogen base with methyl bromide, methyl iodide, and 3-bromo-1-propanol. T...

Hydroxylation and biodegradation of 6-methylquinoline by pseudomonads in aqueous and nonaqueous immobilized-cell bioreactors.

Appl. Environ. Microbiol. 59(7) , 2139-44, (1993)

Selective culturing of pseudomonads that could degrade quinoline led to enrichment cultures and pure cultures with expanded substrate utilization and transformation capabilities for substituted quinol...

The hepatic metabolism of two methylquinolines.

Carcinogenesis 14(5) , 1041-7, (1993)

The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretrea...


More Articles


Related Compounds

  • 3-Iodo-6-methylquinoline
  • 6-Methylquinoline 1-oxide
  • 6-Methylquinoline sulfate
  • 5-Bromo-6-methylquinoline
  • 3-Amino-6-methylquinoline
  • 2-Bromo-6-methylquinoline
  • N-[1-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)piperidin-4-yl]-2-(2-methylphenoxy)acetamide
  • 2-{[(prop-2-en-1-yloxy)carbonyl]amino}-3-(1H-pyrazol-1-yl)propanoic acid
  • 5-(3-fluoro-4-nitrophenyl)-3,6-dihydro-2H-pyran
  • 6-[4-(3-Chlorophenyl)piperazin-1-yl]pyridazine-3-carbonitrile
  • 6-{[4-(Propan-2-yl)phenyl]amino}pyridazine-3-carbonitrile
  • Methyl 2-{[(oxan-3-yl)methyl]sulfanyl}-6-oxo-1-[4-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-5-carboxylate
  • 1-[2-(Oxiran-2-yl)phenyl]pyrrolidine
  • 2-[N,N-Bis(tert-butoxycarbonyl)amino]-6-bromo-3-methylpyridine
  • Tert-butyl 7-oxo-1-azaspiro[5.5]undecane-1-carboxylate
  • 1-(5-fluoropyrimidin-2-yl)-N-(oxan-4-yl)piperidine-3-carboxamide
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