Methapyrilene

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Names

[ CAS No. ]:
91-80-5

[ Name ]:
Methapyrilene

[Synonym ]:
Restryl
Thenylpyramine
N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine
Paradormalene
Methapyrilen
Semikon
Pyrinistol
Thionylan
Pyrinistab
Thenylene
metapyrilene
Tenalin

Chemical & Physical Properties

[ Boiling Point ]:
173 - 175ºC at 3 mm Hg

[ Molecular Formula ]:
C14H19N3S

[ Molecular Weight ]:
261.38600

[ Exact Mass ]:
261.13000

[ PSA ]:
47.61000

[ LogP ]:
2.71130

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT1400000
CHEMICAL NAME :
Pyridine, 2-((2-(dimethylamino)ethyl)-2-thenylamino)-
CAS REGISTRY NUMBER :
91-80-5
BEILSTEIN REFERENCE NO. :
0220729
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C14-H19-N3-S
MOLECULAR WEIGHT :
261.42
WISWESSER LINE NOTATION :
T6NJ BN2N1&1&1- BT5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - aggression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
182 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
77 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
375 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
100 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,420,1983

Safety Information

[ RIDADR ]:
UN 1851

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds

  • normethapyrilene
  • Methapyrilene HCl
  • methapyrilene fumarate
  • Methapyrilene-(dimethyl-d6) fumarate salt
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2,4-Dibromo-6-isopropylphenol
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide