N-Deshydroxyethyl Dasatinib

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Names

[ CAS No. ]:
910297-51-7

[ Name ]:
N-Deshydroxyethyl Dasatinib

[Synonym ]:
N-(2-CHLORO-6-METHYLPHENYL)-2-[[2-METHYL-6-(PIPERAZIN-1-YL)-PYRIMIDIN-4-YL]AMINO]-5-THIAZOLECARBOXAMIDE
Dasatinib metabolite M4
N-(2-chloro-6-methylphenyl)-2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide
N-Deshydroxyethyl Dasatinib
Dasatinib Impurity 6
Target Protein-binding moiety 8

Chemical & Physical Properties

[ Density]:
1.404g/cm3

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C20H22ClN7OS

[ Molecular Weight ]:
443.95300

[ Exact Mass ]:
443.13000

[ PSA ]:
123.31000

[ LogP ]:
4.14860

[ Index of Refraction ]:
1.69

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperazine
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

DownStream

  • Dasatinib Carboxylic Acid Ethyl Ester

Related Compounds

  • N-Deshydroxyethyl Dasatinib-d8
  • N-Boc-N-deshydroxyethyl Dasatinib
  • N-Boc-N-deshydroxyethyl Dasatinib-d8
  • 10-(3-Piperazin-1-ylpropyl)-2-(trifluoromethyl)phenothiazine dihydrochloride
  • N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
  • N-hydroxyquinoline-8-sulfonamide
  • 5-(1,1-dioxo-1lambda6,4-thiazepan-4-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid
  • 5-(2-ethyl-1,4-oxazepan-4-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid
  • 1-[2-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]piperidine-4-carboxylic acid
  • 2-{1-[2-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]pyrrolidin-3-yl}acetic acid
  • 2-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]-N-(propan-2-yl)formamido}acetic acid
  • 3-({4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]phenyl}formamido)-2-methylpropanoic acid
  • 2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methyl-N-(2-methylpropyl)pentanamido]acetic acid
  • 4-({4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)butanoic acid
  • 2-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2,3-trimethylcyclohexyl]formamido}acetic acid
  • (2S,4S)-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]-4-hydroxypyrrolidine-2-carboxylic acid
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