Terbinafine

Suppliers

Names

[ Name ]:
Terbinafine

[Synonym ]:
Lamasil
UNII-G7RIW8S0XP
1-naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-
1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-
S1725_Selleck
Terbinafine
Lamisil AT
trans-N-Methyl-N-(1-naphthylmethyl)-6,6-dimethylhept-2-en-4-ynyl-1-amine
(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
Lamisil
Lamasil (TN)
(2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine
(2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine
SF-86-327
EINECS 245-385-8
MFCD00242672
Lamisil Tablet

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
417.9±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₅N

[ Molecular Weight ]:
291.430

[ Flash Point ]:
183.7±22.3 °C

[ Exact Mass ]:
291.198700

[ PSA ]:
3.24000

[ LogP ]:
6.61

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.586

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ8600000

CHEMICAL NAME :: 1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, (E)-

CAS REGISTRY NUMBER :: 91161-71-6

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C21-H25-N

MOLECULAR WEIGHT :: 291.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 210 mg/kg/6W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Taste) - change in function

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 340,728,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3918 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 27,6087,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 200 mg/kg/40D-I

TOXIC EFFECTS :: Behavioral - anorexia (human) Liver - jaundice, cholestatic Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: JOHEEC Journal of Hepathology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1985- Volume(issue)/page/year: 24,753,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,427,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 213 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: 53XPA8 "Proceedings of the International Congress of Chemotherapy, 13th, Vienna, 1983," Spitzy, K.H., and K. Karrer, eds., 18 vols., Vienna, Austria, Verlag H. Egermann, 1983 Volume(issue)/page/year: 6,116/52,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,427,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 393 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: 53XPA8 "Proceedings of the International Congress of Chemotherapy, 13th, Vienna, 1983," Spitzy, K.H., and K. Karrer, eds., 18 vols., Vienna, Austria, Verlag H. Egermann, 1983 Volume(issue)/page/year: 6,116/52,1983

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(E)-N-(3-CHLOROALLYL)-N-METHYLNAPHTHALEN-2-AMINE
1,1-dichloro-3,3-dimethylbut-1-ene
3,3-Dimethyl-1-Butyne
N-Methyl-1-naphthalenemethylamine hydrochloride
1-chloro-6,6-dimethyl-2-hepten-4-yne
(Z)-3-chloro-N-methyl-N-(naphthalen-1-ylmethyl)prop-2-en-1-amine
tributyl(3,3-dimethylbut-1-ynyl)stannane
(E)-3-iodo-N-methyl-N-(naphthalen-1-ylmethyl)prop-2-en-1-amine

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

terbinafine
Terbinafine-d7
Terbinafine,(Z)
Terbinafine HCl
Isoterbinafine,(E)
Terbinafine lactate
2-(5-Methoxy-1h-indol-3-yl)-4-(4-methoxyphenyl)-1h-imidazole-5-carboxamide
2-(Tert-butoxy)nicotinic acid
N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide
2-Methylphenyl 1-thio-I(2)-D-glucopyranoside
2-Iodopropanedial
2-biphenyl-4-yl-N-(7-fluoro-4-oxo-2-pyrrolidin-1-yl-4H-quinazolin-3-yl)acetamide
2-(4-chlorophenyl)-N-(4-oxo-2-pyrrolidin-1-yl-4H-quinazolin-3-yl)acetamide
2-(3,4-difluorophenyl)-N-(4-oxo-2-pyrrolidin-1-yl-4H-quinazolin-3-yl)acetamide
2-(3,5-difluorophenyl)-N-[2-(isopropyl-methyl-amino)-4-oxo-4H-quinazolin-3-yl]acetamide
2-(3,4-difluorophenyl)-N-[2-(isopropyl-methyl-amino)-4-oxo-4H-quinazolin-3-yl]acetamide

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