Noscapine hydrochloride
Suppliers
Names
[ CAS No. ]:
912-60-7
[ Name ]:
Noscapine hydrochloride
[Synonym ]:
Narcosine hydrochloride
longatinhydrochloride
EINECS 213-014-9
Terbenol hydrochloride
Capval
NOSCAPINE BASE / HCL
MFCD00082546
nectadonhydrochloride
Nectadon hydrochloride
Opian hydrochloride
Vadebex hydrochloride
lyobexhydrochloride
coscopinhydrochloride
Coscopin hydrochloride
1,3-Dioxolo[4,5-g]isoquinolinium, 5-[(1S)-1,3-dihydro-4,5-dimethoxy-3-oxo-1-isobenzofuranyl]-5,6,7,8-tetrahydro-4-methoxy-6-methyl-, chloride, (5R)- (1:1)
Narcompren hydrochloride
opianhydrochloride
capvalhydrochloride
Opianine hydrochloride
vadebexhydrochloride
(5R)-5-[(1S)-4,5-Dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride
Methoxyhydrastine hydrochloride
Noscapine HCl
Noscapine hydrochloride
Narcotine hydrochloride
Chemical & Physical Properties
[ Density]:
1.332g/cm3
[ Boiling Point ]:
565.3ºC at 760mmHg
[ Melting Point ]:
221-223ºC
[ Molecular Formula ]:
C22H24ClNO7
[ Molecular Weight ]:
449.882
[ Flash Point ]:
295.7ºC
[ Exact Mass ]:
449.124115
[ PSA ]:
75.69000
[ LogP ]:
3.62170
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NP7225000
- CHEMICAL NAME :
- 1(3H)Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methy l-1,3-dioxolo (4,5-g)isoquinolin-5-yl)-, hydrochloride, (S-(R*,S*))-
- CAS REGISTRY NUMBER :
- 912-60-7
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C22-H23-N-O7.Cl-H
- MOLECULAR WEIGHT :
- 449.92
- WISWESSER LINE NOTATION :
- T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 853 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 581 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 52 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 83 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 60 mg/L
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
3
[ RTECS ]:
NP7225000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Precursor & DownStream
Precursor
DownStream
Articles
Pharm. Dev. Technol. 20(2) , 169-75, (2015)
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches....