Noscapine hydrochloride

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Names

[ CAS No. ]:
912-60-7

[ Name ]:
Noscapine hydrochloride

[Synonym ]:
Narcosine hydrochloride
longatinhydrochloride
EINECS 213-014-9
Terbenol hydrochloride
Capval
NOSCAPINE BASE / HCL
MFCD00082546
nectadonhydrochloride
Nectadon hydrochloride
Opian hydrochloride
Vadebex hydrochloride
lyobexhydrochloride
coscopinhydrochloride
Coscopin hydrochloride
1,3-Dioxolo[4,5-g]isoquinolinium, 5-[(1S)-1,3-dihydro-4,5-dimethoxy-3-oxo-1-isobenzofuranyl]-5,6,7,8-tetrahydro-4-methoxy-6-methyl-, chloride, (5R)- (1:1)
Narcompren hydrochloride
opianhydrochloride
capvalhydrochloride
Opianine hydrochloride
vadebexhydrochloride
(5R)-5-[(1S)-4,5-Dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride
Methoxyhydrastine hydrochloride
Noscapine HCl
Noscapine hydrochloride
Narcotine hydrochloride

Chemical & Physical Properties

[ Density]:
1.332g/cm3

[ Boiling Point ]:
565.3ºC at 760mmHg

[ Melting Point ]:
221-223ºC

[ Molecular Formula ]:
C22H24ClNO7

[ Molecular Weight ]:
449.882

[ Flash Point ]:
295.7ºC

[ Exact Mass ]:
449.124115

[ PSA ]:
75.69000

[ LogP ]:
3.62170

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NP7225000
CHEMICAL NAME :
1(3H)Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methy l-1,3-dioxolo (4,5-g)isoquinolin-5-yl)-, hydrochloride, (S-(R*,S*))-
CAS REGISTRY NUMBER :
912-60-7
LAST UPDATED :
199009
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H23-N-O7.Cl-H
MOLECULAR WEIGHT :
449.92
WISWESSER LINE NOTATION :
T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
853 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
581 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
83 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
60 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

[ RTECS ]:
NP7225000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Precursor & DownStream

Precursor

DownStream

  • 6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
  • Meconine
  • hydrocotarnine
  • 6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Articles

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharm. Dev. Technol. 20(2) , 169-75, (2015)

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches....


More Articles

Related Compounds

  • Noscapine
  • Triprolidine hydrochloride
  • Elacridar hydrochloride
  • Tyrocidine, hydrochloride
  • dodecylamine hydrochloride
  • Minoxidil hydrochloride
  • 4-ethoxy-N-(3-methoxypropyl)-2,3-dimethylbenzenesulfonamide
  • 1-[(5-Methoxy-2,4-dimethylphenyl)sulfonyl]-2-methylpiperidine
  • Ethyl 2-(4,5-dichloro-2-methylbenzenesulfonamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • 1-(5-Iodo-2-methoxybenzenesulfonyl)-2-methylpiperidine
  • 1-[(4-Ethoxy-2,5-dimethylphenyl)sulfonyl]-2-methylpiperidine
  • 5-isopropyl-2-methoxy-N-(1,3-thiazol-2-yl)benzenesulfonamide
  • Ethyl 1-[4-(4-{[3-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}phenoxy)benzenesulfonyl]piperidine-3-carboxylate
  • 2-Ethyl-1-(2-methoxy-5-methylbenzenesulfonyl)piperidine
  • 4-Ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxylic acid
  • Ethyl 1-[(4'-{[3-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}-[1,1'-biphenyl]-4-yl)sulfonyl]piperidine-3-carboxylate
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