methacycline
Suppliers
Names
[ CAS No. ]:
914-00-1
[ Name ]:
methacycline
[Synonym ]:
Germicilclin
Adriamicina
gs-2876
6-methylene-oxytetracyclin
METHACYCLINE
Globociclina
6-methyleneoxytetracycline
rondomycin
metacycline
bialatan
methacyclineamphoteric
Cyclobiotic
12aalpha))-ph
Chemical & Physical Properties
[ Density]:
1.66g/cm3
[ Boiling Point ]:
695.1ºC at 760mmHg
[ Melting Point ]:
>150°C (dec.) (lit.)
[ Molecular Formula ]:
C22H22N2O8
[ Molecular Weight ]:
442.41900
[ Flash Point ]:
374.2ºC
[ Exact Mass ]:
442.13800
[ PSA ]:
181.62000
[ LogP ]:
0.26240
[ Index of Refraction ]:
1.753
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9275000
- CHEMICAL NAME :
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
- CAS REGISTRY NUMBER :
- 914-00-1
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H22-N2-O8
- MOLECULAR WEIGHT :
- 442.46
- WISWESSER LINE NOTATION :
- L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 3750 ug/L
- REFERENCE :
- BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)