phenyltoloxamine

Suppliers

Names

[ CAS No. ]:
92-12-6

[ Name ]:
phenyltoloxamine

[Synonym ]:
Feniltolossamina [DCIT]
Phenyltoloxamine
Phenoxadrine
Antin
[2-(2-benzyl-phenoxy)-ethyl]-dimethyl-amine
Histionex
2-Dimethylamino-1-(2-benzyl-phenoxy)-aethan
Bistrimin
Phenoxadrin
UNII-K65LB6598J
Phenyl-toloxamin
Phentoloxamine
Bristamin
[2-(2-Benzyl-phenoxy)-aethyl]-dimethyl-amin

Chemical & Physical Properties

[ Density]:
1.022g/cm3

[ Boiling Point ]:
359.2ºC at 760 mmHg

[ Molecular Formula ]:
C17H21NO

[ Molecular Weight ]:
255.35500

[ Flash Point ]:
106ºC

[ Exact Mass ]:
255.16200

[ PSA ]:
12.47000

[ LogP ]:
3.21780

[ Index of Refraction ]:
1.552

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH2376000
CHEMICAL NAME :
Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-
CAS REGISTRY NUMBER :
92-12-6
BEILSTEIN REFERENCE NO. :
1986598
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C17-H21-N-O
MOLECULAR WEIGHT :
255.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1127 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
246 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83250 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

Synthetic Route

Precursor & DownStream

Precursor

  • 2-Benzylphenol
  • 2-benzylphenol-2-bromoethylether
  • Dimethylamine
  • sodium o-benzylphenolate
  • 2-Chloroethyldimethylamine

DownStream

  • 2-(2-benzylphenoxy)ethyl-trimethylazanium,iodide

Related Compounds

  • Phenyltoloxamine citrate
  • Phenyltoloxamine bisulfate
  • N-Desmethyl Phenyltoloxamine Hydrochloride
  • N-{[1-(3,4-difluorophenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-2-(3-methylphenoxy)acetamide
  • N-{[1-(4-fluorophenyl)-1H-1,2,3,4-tetrazol-5-yl]methyl}-2-(3-methylphenoxy)acetamide
  • N-{1-[1-(2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-3-methyl-1H-pyrazol-5-yl}-2-(3-methylphenoxy)acetamide
  • N-(1-benzoyl-1,2,3,4-tetrahydroquinolin-7-yl)-2-(3-methylphenoxy)acetamide
  • N-[1-(4-fluorobenzenesulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl]-2-(3-methylphenoxy)acetamide
  • (5-(2,4-Difluorophenyl)isoxazol-3-yl)methyl 2-(m-tolyloxy)acetate
  • 8-(3-Methylbenzenesulfonyl)-3-(2-phenoxyethyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
  • 6-Bromo-2-chloro-5-methylquinoline
  • 3-methyl-N-(2-(2-(thiophen-2-yl)thiazolo[3,2-b][1,2,4]triazol-6-yl)ethyl)benzenesulfonamide
  • 3-methyl-N-(4-((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)phenyl)benzenesulfonamide
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