Toluidine Blue
Suppliers
Names
[ CAS No. ]:
92-31-9
[ Name ]:
Toluidine Blue
[Synonym ]:
Methanaminium, N-(7-amino-8-methyl-3H-phenothiazin-3-ylidene)-N-methyl-, chloride (1:1)
PHENOTHIAZIN-5-IUM, 3-AMINO-7-(DIMETHYLAMINO)-2-METHYL-, CHLORIDE
Toluidine Blue O, pure
3-Amino-7-dimethylamino-2-methylphenazathionium Chloride
3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)
EINECS 202-146-2
(7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium,chloride
3-Amino-7-(dimethylamino)-2-methylphenothiazinium chloride
Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
MFCD00011934
T C666 BN ISJ E1 FZ LN1&1 &&Chloride
Tolonium chloride (C.I. 52040)
7-Amino-N,N,8-trimethyl-3H-phenothiazin-3-iminium chloride
Chemical & Physical Properties
[ Molecular Formula ]:
C15H16ClN3S
[ Molecular Weight ]:
305.826
[ Exact Mass ]:
305.075348
[ PSA ]:
70.39000
[ LogP ]:
1.27240
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP5670000
- CHEMICAL NAME :
- Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
- CAS REGISTRY NUMBER :
- 92-31-9
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C15-H16-N3-S.Cl
- MOLECULAR WEIGHT :
- 305.85
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 43 mg/kg/6D
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 215 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28930 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27560 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 13440 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20 umol/L/5H (Continuous)
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1164 No. of Facilities: 224 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1226 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1164 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 7956 (estimated) No. of Female Employees: 5824 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
F+
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
SP5670000
[ HS Code ]:
32041300
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934300000
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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