Biphenyl
Suppliers
Names
[ CAS No. ]:
92-52-4
[ Name ]:
Biphenyl
[Synonym ]:
MFCD00003054
EINECS 202-163-5
Bibenzene
PHPH
Xenene
Lemonene
DIPHENYL
Biphenyl
carolidal
cp390
mcs1572
FEMA 3129
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
255 °C at 760 mmHg
[ Melting Point ]:
70ºC
[ Molecular Formula ]:
C12H10
[ Molecular Weight ]:
154.208
[ Flash Point ]:
105.5±8.9 °C
[ Exact Mass ]:
154.078247
[ LogP ]:
3.98
[ Vapour density ]:
5.31 (vs air)
[ Vapour Pressure ]:
0.0±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.571
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidising agents.
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DU8050000
- CHEMICAL NAME :
- Biphenyl
- CAS REGISTRY NUMBER :
- 92-52-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 64
- MOLECULAR FORMULA :
- C12-H10
- MOLECULAR WEIGHT :
- 154.22
- WISWESSER LINE NOTATION :
- RR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE 19810) ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 4400 ug/m3
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2140 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - alteration in gastric secretion
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >200 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE 19810)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >2600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5010 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE 19810) ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3300 mg/kg/15D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41250 mg/kg/24W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/m3/7H/94D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - emphysema Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg/3D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/m3/7H/92D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 gm/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 46 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,1635,1977 *** REVIEWS *** ACGIH TLV-TWA 1.3 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.2 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,94,1971 OSHA PEL (Gen Indu):8H TWA 0.2 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.2 ppm (1.3 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.2 ppm (1 mg/m3);STEL 0.6 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL-INDIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-SWEDEN:TWA 0.2 ppm (1.3 mg/m3);STEL 0.4 ppm (2.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (1.3 mg/m3) JAN 1993 OEL-THAILAND:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.6 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIPHENYL-air:10H TWA 0.2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 27590 No. of Facilities: 281 (estimated) No. of Industries: 10 No. of Occupations: 29 No. of Employees: 10589 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 27590 No. of Facilities: 2220 (estimated) No. of Industries: 20 No. of Occupations: 36 No. of Employees: 32003 (estimated) No. of Female Employees: 3708 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335-H410
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38;R50/53
[ Safety Phrases ]:
S23-S60-S61
[ RIDADR ]:
UN 3077
[ WGK Germany ]:
2
[ RTECS ]:
DU8050000
[ Packaging Group ]:
III
[ Hazard Class ]:
9.0
[ HS Code ]:
2902909010
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2902909010
[ Summary ]:
2902909010 1,1'-biphenyl。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:2.0%。General tariff:30.0%
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