1-Phenylpiperazine

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Names

[ CAS No. ]:
92-54-6

[ Name ]:
1-Phenylpiperazine

[Synonym ]:
phenyl piperazine
MFCD00005957
1-phenyl-piperazine
4-Phenylpiperazine
Phenylpiperazine
1-Fenylpiperazin
1-PHENYLPIPERAZINE
1-fenylpiperazine
N-PHENYLPIPERAZINE
1-PHENYLPIPERAINE
EINECS 202-165-6
4-Ph-piperazine
Piperazine, 1-phenyl-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
287.2±15.0 °C at 760 mmHg

[ Melting Point ]:
18.8 °C

[ Molecular Formula ]:
C₁₀H₁₄N₂

[ Molecular Weight ]:
162.232

[ Flash Point ]:
138.3±11.4 °C

[ Exact Mass ]:
162.115692

[ PSA ]:
15.27000

[ LogP ]:
1.11

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
Store in dark!

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2625000

CHEMICAL NAME :: Piperazine, 1-phenyl-

CAS REGISTRY NUMBER :: 92-54-6

BEILSTEIN REFERENCE NO. :: 0132157

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H14-N2

MOLECULAR WEIGHT :: 162.26

WISWESSER LINE NOTATION :: T6M DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 140 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 900 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,99,1992

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H314

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R22;R24;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2922 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TM2625000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29335995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

tert-butyl 4-phenylpiperazine-1-carboxylate
1-phenylpiperazin-1-ium chloride
Piperazine
Chlorobenzene
1-allyl-4-phenyl-piperazine
Bromobenzene
Bis(2-Chloroethyl)amine hydrochloride
3-BROMO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDINE
Iodobenzene

DownStream

1-pentyl-4-phenylpiperazine
1-Phenyl-4-propylpiperazine
methyl 4-phenylpiperazine-1-carbodithioate
1-(3-chloropropyl)-4-phenylpiperazine
1-benzyl-4-phenylpiperazine
1-Boc-4-(4-Bromophenyl)piperazine
1-Methyl-4-phenylpiperazine
1-(Diphenylmethyl)-4-phenylpiperazine
1-naphthalen-1-yl-4-phenylpiperazine
1-(4-biphenylyl)-piperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

J. Med. Chem. 53(6) , 2510-20, (2010)

Modification of the partial dopamine type 2 receptor (D(2)) agonist 3-(1-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D(2) antagonists with fast-off kinetic properties. A re...

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

J. Med. Chem. 52(15) , 4923-35, (2009)

Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2,...

Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.

J. Chromatogr. A. 1217(40) , 6274-80, (2010)

A simple and sensitive procedure, using p-tolylpiperazine (pTP) as internal standard (IS), has been developed and validated for the qualitative and quantitative analysis of 1-(3-trifuoromethylphenyl)p...

1-PHENYLPIPERAZINE
1-Phenylpiperazine HCl
1-Phenylpiperazine HCl
1-phenylpiperazine-2-one
1-Phenylpiperazine maleate
4-amino-1-phenylpiperazine
1,4-Dimethyl-3-(3-methylbutyl)-1H-pyrazol-5-amine
2-Chloro-4-[(3-methylbutan-2-yl)amino]benzonitrile
n-((2-Methoxypyridin-3-yl)methyl)-2,6-dimethylpyrimidin-4-amine
2,5-difluoro-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide
2-fluoro-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide
4-fluoro-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide
3-fluoro-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide
4-(4-Cyclopentylpiperazin-1-yl)quinazoline
2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-pyrrol-2-yl)-2-(pyrrolidin-1-yl)ethyl)ethanesulfonamide
3-Butyl-1,4-dimethyl-1H-pyrazol-5-amine

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