Proflavine
Suppliers
Names
[ CAS No. ]:
92-62-6
[ Name ]:
Proflavine
[Synonym ]:
3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin
acridine-3,6-diamine
3,6-Acridinediamine
Chemical & Physical Properties
[ Density]:
1.346 g/cm3
[ Boiling Point ]:
506.9ºC at 760 mmHg
[ Melting Point ]:
260ºC
[ Molecular Formula ]:
C13H11N3
[ Molecular Weight ]:
209.24700
[ Flash Point ]:
292.9ºC
[ Exact Mass ]:
209.09500
[ PSA ]:
64.93000
[ LogP ]:
3.71480
[ Index of Refraction ]:
1.833
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AR8670000
- CHEMICAL NAME :
- Acridine, 3,6-diamino-
- CAS REGISTRY NUMBER :
- 92-62-6
- BEILSTEIN REFERENCE NO. :
- 0166050
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 42
- MOLECULAR FORMULA :
- C13-H11-N3
- MOLECULAR WEIGHT :
- 209.27
- WISWESSER LINE NOTATION :
- T C666 BNJ EZ MZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 11111 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 13500 nmol/L
- REFERENCE :
- ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated)
Safety Information
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%