Proflavine

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Names

[ CAS No. ]:
92-62-6

[ Name ]:
Proflavine

[Synonym ]:
3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin
acridine-3,6-diamine
3,6-Acridinediamine

Chemical & Physical Properties

[ Density]:
1.346 g/cm3

[ Boiling Point ]:
506.9ºC at 760 mmHg

[ Melting Point ]:
260ºC

[ Molecular Formula ]:
C₁₃H₁₁N₃

[ Molecular Weight ]:
209.24700

[ Flash Point ]:
292.9ºC

[ Exact Mass ]:
209.09500

[ PSA ]:
64.93000

[ LogP ]:
3.71480

[ Index of Refraction ]:
1.833

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR8670000

CHEMICAL NAME :: Acridine, 3,6-diamino-

CAS REGISTRY NUMBER :: 92-62-6

BEILSTEIN REFERENCE NO. :: 0166050

LAST UPDATED :: 199806

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C13-H11-N3

MOLECULAR WEIGHT :: 209.27

WISWESSER LINE NOTATION :: T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 11111 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 13500 nmol/L

REFERENCE :: ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated)

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Proflavine hydrochloride
Benzenamine,4,4'-methylenebis[3-nitro-
m-Phenylenediamine
N,N'-bis(3-aminophenyl)urea
3,6-Diamino-9(10H)-acridone
4,4′-methylenedianiline
Glycerol
Oxalic acid

DownStream

Acetamide,N,N'-3,6-acridinediylbis-
N-[6-[(4-methylphenyl)sulfonylamino]acridin-3-yl]acetamide
N-(6-aminoacridin-3-yl)acetamide
3,6-dihydroxy-4,5-dimethylacridine
6-hydroxy-10H-acridin-3-one
acridin-3-ylamine
3,6-diisothiocyanatoacridine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%