4-Biphenylol

Suppliers

Names

[ CAS No. ]:
92-69-3

[ Name ]:
4-Biphenylol

[Synonym ]:
P-PHENYLPHENOL
p-hydroxybiphenyl
1, 4-PHENYLPHENOL
4-Biphenylol
[1,1'-Biphenyl]-4-ol
Hydroxy diphenyl
tetrosinp300
4-PHENYLPHENOL/BIPHENYL-4-OL/4-HYDROXYBIPHENYL
PARAXENOL
4-PHENYL PHENOL
Tetrasin P 300
4-hydroxy-1,1'-biphenyl
MFCD00002347
P-HYDROXYDIPHENYL
4-HYDROXY BIPHENYL
4-HYDROXY DIPHENYL
4-DIHYDROXYBIPHENYL
4-Diphenylol
4-HYDROXYDIPHENYL
4-hydroxybiphenyl
2-DIPHENYLOL
p-Biphenylol
Biphenyl-4-ol
4-Phenylphenol
4-HYDROXYBIPHENYL(P-PHENYLPHENOL)
BIPHENYL-4-OL FOR SYNTHESIS
QR DR
EINECS 202-179-2
4-HYDROXYBIPHENYL (4-PHENYLPHENOL)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
306.4±11.0 °C at 760 mmHg

[ Melting Point ]:
164-166 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₀O

[ Molecular Weight ]:
170.207

[ Flash Point ]:
165.6±0.0 °C

[ Exact Mass ]:
170.073166

[ PSA ]:
20.23000

[ LogP ]:
3.20

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases, halogens. Combustible.

[ Water Solubility ]:
0.7 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV5850000

CHEMICAL NAME :: 4-Biphenylol

CAS REGISTRY NUMBER :: 92-69-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H10-O

MOLECULAR WEIGHT :: 170.22

WISWESSER LINE NOTATION :: QR DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84022 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84022 No. of Facilities: 216 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 649 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H411

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R38;R51/53

[ Safety Phrases ]:
S26-S36/37-S61-S36

[ RIDADR ]:
UN3077

[ WGK Germany ]:
2

[ RTECS ]:
DV5850000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
29071900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Bromobiphenyl
4-Chlorophenol
Phenylboronic acid
Iodobenzene
4-Hydroxyphenylboronic acid
4-Iodobiphenyl
4-Methoxybiphenyl
4-Iodophenol
4-Bromophenol
4-Benzyloxy-biphenyl

DownStream

ethyl 4-(4-phenylphenoxy)butanoate
TFIIH Modulator19
5-PHENYL-O-ANISIDINE
3-(Trifluoromethyl)-1H-pyrazole-5-carboxamide
Propanoic acid,2-([1,1'-biphenyl]-4-yloxy)-
4'-Methoxybiphenyl-4-carbaldehyde
4,4'-Dihydroxybiphenyl
4-Biphenylol
4-Phenylcyclohexanone
2-(4-phenylphenoxy)ethanol

Customs

[ HS Code ]: 2907199090

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

J. Med. Chem. 48 , 2469-79, (2005)

A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities. These CXCL8 inhibitors are derivatives of phe...

Influences of exogenous probiotics and tea polyphenols on the production of three acids during the simulated colonic fermentation of maize resistant starch.

J. Food Sci. Technol. 52 , 5874-81, (2015)

In the present study, influences of nine probiotics and tea polyphenols on the production of acetic, butyric, and lactic acid from simulated colonic fermentation of maize resistant starch (RS) were in...