Phenothiazine
Suppliers
Names
[ CAS No. ]:
92-84-2
[ Name ]:
Phenothiazine
[Synonym ]:
Thiodiphenylamine
Dibenzothiazine
Phenosan
EINECS 202-196-5
Antiverm
Phenthiazine
Agrazine
PHENOTHIAZINE
Feeno
MFCD00005015
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
371.0±12.0 °C at 760 mmHg
[ Melting Point ]:
184 °C
[ Molecular Formula ]:
C12H9NS
[ Molecular Weight ]:
199.272
[ Flash Point ]:
178.2±19.6 °C
[ Exact Mass ]:
199.045563
[ PSA ]:
37.33000
[ LogP ]:
4.15
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.675
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
[ Water Solubility ]:
2 mg/L (25 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SN5075000
- CHEMICAL NAME :
- Phenothiazine
- CAS REGISTRY NUMBER :
- 92-84-2
- BEILSTEIN REFERENCE NO. :
- 0143237
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 28
- MOLECULAR FORMULA :
- C12-H9-N-S
- MOLECULAR WEIGHT :
- 199.28
- WISWESSER LINE NOTATION :
- T C666 BM ISJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 425 mg/kg/5D
- TOXIC EFFECTS :
- Behavioral - headache Liver - jaundice, other or unclassified Blood - normocytic anemia
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 242,86,1942
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00586
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cattle
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1104,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 66,888,1944 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- REFERENCE :
- AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,204,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOTHIAZINE-air:10H TWA 5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84116 No. of Facilities: 175 (estimated) No. of Industries: 5 No. of Occupations: 15 No. of Employees: 5639 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84116 No. of Facilities: 5473 (estimated) No. of Industries: 54 No. of Occupations: 68 No. of Employees: 88048 (estimated) No. of Female Employees: 8791 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H317-H373-H412
[ Precautionary Statements ]:
P273-P280
[ Target Organs ]:
Blood
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R36/38;R43;R51/53
[ Safety Phrases ]:
S26-S36-S61-S36/37/39-S29
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
SN5075000
[ HS Code ]:
29343090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934300000
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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