2-Chloroacrylonitrile

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Names

[ CAS No. ]:
920-37-6

[ Name ]:
2-Chloroacrylonitrile

[Synonym ]:
2-chloro-acrylonitrile
2-CHLOROCYANOETHYLENE
1-Chloroaerylonitrile
MFCD00001858
2-PROPENONITRLLE
Chloroacrylonitrile
2-Propenenitrile, 2-chloro-
2-chloro-acrylonitril
NCYGU1
2-Chloroacrylonitrile
β-Chloroacrylonitrile
2-CHLORACRYLONITRIL
EINECS 213-055-2
2-Chloroprop-2-enenitrile
1-Cyanovinyl chloride
2-chloroacrylnitrile

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
89.5±13.0 °C at 760 mmHg

[ Melting Point ]:
−65 °C(lit.)

[ Molecular Formula ]:
C₃H₂ClN

[ Molecular Weight ]:
87.508

[ Flash Point ]:
6.7±0.0 °C

[ Exact Mass ]:
86.987579

[ PSA ]:
23.79000

[ LogP ]:
0.34

[ Vapour Pressure ]:
58.4±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.435

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AT5525000

CHEMICAL NAME :: Acrylonitrile, 2-chloro-

CAS REGISTRY NUMBER :: 920-37-6

BEILSTEIN REFERENCE NO. :: 0773744

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H2-Cl-N

MOLECULAR WEIGHT :: 87.51

WISWESSER LINE NOTATION :: NCYGU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 304 mg/m3/6H

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(2),52,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02164

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H300 + H310 + H330-H314-H334-H350-H400

[ Precautionary Statements ]:
P201-P210-P260-P280-P284-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313-P403 + P233

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R23/24;R28;R36/37/38;R40

[ Safety Phrases ]:
S53-S26-S36/37/39-S45-S61-S28A-S16-S1

[ RIDADR ]:
UN 3383 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AT5525000

[ Packaging Group ]:
II

[ Hazard Class ]:
3.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,3-Dichloropropanenitrile
Acrylonitrile
Propanenitrile, 2-chloro-3-[(4-nitrophenyl)thio]
Propanenitrile,2,2,3-trichloro-
3-Chloro-2-acetyloxypropanenitrile
POTASSIUM CYANIDE
Chlorine
Chloroform
Hydroquinone

DownStream

2-chloro-3-(4-chlorophenyl)sulfonylpropanenitrile
1-isopropyl-1H-pyrazol-3-amine
2-Isopropyl-2H-pyrazol-3-ylamine
2-Acetylthiophene-3-amine
ethyl 3-aminothiophene-2-carboxylate
3-(4-bromophenyl)sulfonylprop-2-enenitrile
2-chloro-3-(4-methylphenyl)sulfonylpropanenitrile
2-ethoxyprop-2-enenitrile
Ethyl 2-(4-cyano-1H-1,2,3-triazol-1-yl)acetate
N-Acetylcyclopentane-1-amine

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Structure-nephrotoxicity relationships of glutathione pathway intermediates derived from organic solvents.

Toxicology 56(1) , 47-61, (1989)

The nephrotoxicity of glutathione (GSH) pathway metabolites derived from toluene (TOL), styrene (STYR), bromobenzene (BB), acrylonitrile (ACLN) and 2-chloroacrylonitrile (CACLN) were compared with tha...

[Information from the Soviet Toxicology Center].

Gig. Tr. Prof. Zabol. (2) , 52-3, (1983)

Dual-function cinchona alkaloid catalysis: catalytic asymmetric tandem conjugate addition-protonation for the direct creation of nonadjacent stereocenters.

J. Am. Chem. Soc. 128(12) , 3928-30, (2006)

Catalytic tandem asymmetric reactions constitute a powerful strategy for the asymmetric construction of nonadjacent stereocenters in acyclic molecules directly from achiral precursors. In this Communi...

2-chloroacrylonitrile
3,3-bis(4-nitrophenoxy)-2-chloroacrylonitrile
2-methyl-2-methylsulfanylpropanenitrile
2-(4-methoxyphenyl)-4-nitrobenzoic acid
2-[(4-aminobenzoyl)-benzylamino]ethyl-diethylazanium,chloride
2-(4-methoxyphenyl)-5-methylbenzoic acid
3-Methyl-4-pyridin-2-ylisoxazolo[3,4-d]pyridazin-7(6h)-one
Ethyl [(piperidin-4-yl)(propyl)carbamoyl]formate
Ethyl 2-[(4-methylphenyl)amino]propanoate
5-(4,5-Dimethyl-4h-1,2,4-triazol-3-yl)-4-methylthiophen-2-amine
2-(3-Bromo-4,5-dimethoxyphenyl)ethanamine
1-[3-(Benzyloxy)phenyl]propan-2-amine
4-(3-Chlorophenyl)pyridazine-3,6-diol
N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}prop-2-enamide
1-(1-ethyl-1H-pyrazol-4-yl)cyclohexan-1-amine
4-(Heptyloxy)-2-(trifluoromethyl)benzoic acid

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