Fotemustine

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Names

[ Name ]:
Fotemustine

[Synonym ]:
Phosphonic acid, P-[1-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-, diethyl ester
MFCD00866278
Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate
1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
Fotemustine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
188 °C(lit.)

[ Melting Point ]:
85ºC

[ Molecular Formula ]:
C₉H₁₉ClN₃O₅P

[ Molecular Weight ]:
315.691

[ Flash Point ]:
104 °F

[ Exact Mass ]:
315.075073

[ PSA ]:
107.11000

[ LogP ]:
1.26

[ Index of Refraction ]:
1.524

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7115500

CHEMICAL NAME :: Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethy l)-, diethyl ester

CAS REGISTRY NUMBER :: 92118-27-9

LAST UPDATED :: 199410

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H19-Cl-N3-O5-P

MOLECULAR WEIGHT :: 315.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R10:Flammable. R36/37:Irritating to eyes and respiratory system . R43:May cause sensitization by skin contact.

[ Safety Phrases ]:
S16-S26-S36

[ RIDADR ]:
UN 3336 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature.

Tumori 99(5) , e237-40, (2013)

Extracranial metastases from glioblastoma multiforme (GBM) are a very rare event, even if an increasing incidence has been documented. We report the case of a young woman with primary GBM who develope...

Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma.

J. Transl. Med. 11 , 38, (2013)

The effect of the addition of fotemustine and/or interferon (IFN) to standard therapy with dacarbazine alone in patients with advanced malignant melanoma was investigated in a multicenter, randomized ...

Good clinical activity and favorable toxicity profile of once weekly bortezomib, fotemustine, and dexamethasone (B-MuD) for the treatment of relapsed multiple myeloma.

Am. J. Hematol. 88(2) , 102-6, (2013)

Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new thre...

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