methylpropiolate

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Names

[ CAS No. ]:
922-67-8

[ Name ]:
methylpropiolate

[Synonym ]:
Methyl propiolate
Propynoic acid, methyl ester
EINECS 213-083-5
methyl prop-2-ynoate
methylpropiolate
Propynoic acid methyl ester
2-Propynoic acid, methyl ester (9CI)
Methyl acetylenecarboxylate
Methyl propynoate
MFCD00008572
2-Propynoic acid, methyl ester

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
104.0±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H4O2

[ Molecular Weight ]:
84.073

[ Flash Point ]:
10.0±0.0 °C

[ Exact Mass ]:
84.021126

[ PSA ]:
26.30000

[ LogP ]:
0.89

[ Vapour Pressure ]:
31.4±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.408

[ Storage condition ]:
Refrigerator (+4°C) + Flammables area

[ Stability ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents, bases, acids.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE0050000
CHEMICAL NAME :
Propiolic acid, methyl ester
CAS REGISTRY NUMBER :
922-67-8
BEILSTEIN REFERENCE NO. :
0605462
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H4-O2
MOLECULAR WEIGHT :
84.08
WISWESSER LINE NOTATION :
1UU1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08364

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;Xi:Irritant;

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S23-S16

[ RIDADR ]:
UN 3272 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UE0050000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29161980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanol
  • Propiolic acidd
  • imino-[2-(4-nitrophenyl)-2-oxo-ethylidene]azanium
  • Benzonitrile
  • methyl iodide
  • methyl (1S,3aS)-1H-1,3a-ethenoazulene-3-carboxylate
  • janusene carboxylate-5a de methyle
  • diepoxy-1,4,5,8 hexahydro-1,4,4a,5,8,8a naphtalene carboxylate-4a de methyle

DownStream

  • METHYL 1-METHYL-1,2,3-TRIAZOLE-5-CARBOXYLATE
  • METHYL 1-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLATE
  • methyl 3-(2,2,6,6-tetramethyl-4-oxopiperidin-1-yl)prop-2-enoate
  • methyl 1-methyl-9H-carbazole-3-carboxylate
  • 1-Methyl-9H-carbazol-2-carbonsaeure-methylester
  • methyl 3-hydroxy-2-methylidene-3-propylhexanoate
  • methyl 3-methylselanylprop-2-enoate
  • Methyl 4-ethoxybenzoate
  • Methyl 3-ethoxybenzoate
  • methyl (E)-3-morpholin-4-ylprop-2-enoate

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Predator lipids induce paralytic shellfish toxins in bloom-forming algae.

Proc. Natl. Acad. Sci. U. S. A. 112 , 6395-400, (2015)

Interactions among microscopic planktonic organisms underpin the functioning of open ocean ecosystems. With few exceptions, these organisms lack advanced eyes and thus rely largely on chemical sensing...

Determination of glutathione in baker's yeast by capillary electrophoresis using methyl propiolate as derivatizing reagent.

J. Chromatogr. A. 1300 , 204-8, (2013)

In this study we demonstrate - for the first time - the suitability of methyl propiolate - an alkylester of propiolic acid - as a thiol derivatizing reagent for capillary electrophoresis. Glutathione ...

Synthesis of tetrahydropyrimidin-2-ones via FeCl3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea.

Mol. Divers. 18(1) , 79-89, (2014)

Polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives could be selectively produced from the one-pot domino reaction of arylamines, methyl propiolate, aromatic aldehydes, and u...


More Articles

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