2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride

Names

[ CAS No. ]:
92564-34-6

[ Name ]:
2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride

[Synonym ]:
HA 1004 hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
575.2ºC at 760 mmHg

[ Melting Point ]:
235-236ºC

[ Molecular Formula ]:
C₁₂H₁₆ClN₅O₂S

[ Molecular Weight ]:
329.80600

[ Flash Point ]:
301.7ºC

[ Exact Mass ]:
329.07100

[ PSA ]:
129.34000

[ LogP ]:
3.46080

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

S-Methylisothiourea sulfate
H-9 dihydrochloride
ISOQUINOLINE-5-SULFONYL CHLORIDE

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Human erythropoietin receptor increases GATA-2 and Bcl-xL by a protein kinase C-dependent pathway in human erythropoietin-dependent cell line AS-E2.

Cell Growth Differ. 8 , 1317-1328, (1997)

Erythropoietin (Epo) is a cytokine known to stimulate proliferation and differentiation of erythroid cells. However, recent gene disruption experiments demonstrated that Epo receptor signaling is not ...

cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression.

J. Biol. Chem. 272 , 3238-3245, (1997)

We investigated the inhibitory effects of intracellular cyclic adenosine monophosphate (cAMP) levels in regulating class 3 aldehyde dehydrogenase (aldh3) gene expression using cultures of primary rat ...

Regulation of Schwann cell proliferation in cultured segments of the adult rat sciatic nerve.

J. Neurosci. Res. 52 , 530-537, (1998)

Schwann cell proliferation was studied in cultured segments of the rat sciatic nerve by measurement of [3H] thymidine incorporation or through bromodeoxyuridine-(BrdU)-labelling and immunocytochemistr...