2-Butynedioate, potassium salt (1:1)

Names

[ CAS No. ]:
928-04-1

[ Name ]:
2-Butynedioate, potassium salt (1:1)

[Synonym ]:
potassium,4-hydroxy-4-oxobut-2-ynoate
EINECS 213-169-2
2-Butynedioate, potassium salt (1:1)
MFCD04687516

Chemical & Physical Properties

[ Boiling Point ]:
362.4ºC at 760 mmHg

[ Melting Point ]:
133 °C

[ Molecular Formula ]:
C₄HKO₄

[ Molecular Weight ]:
151.139

[ Flash Point ]:
187.2ºC

[ Exact Mass ]:
150.943909

[ PSA ]:
77.43000

[ Storage condition ]:
-20°C

[ Stability ]:
Stable. Incompatible with bases, reducing agents, oxidizing agents.

[ Water Solubility ]:
slightly soluble (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AP0700000

CHEMICAL NAME :: Acetylenedicarboxylic acid, monopotassium salt

CAS REGISTRY NUMBER :: 928-04-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H-O4.K

MOLECULAR WEIGHT :: 152.15

WISWESSER LINE NOTATION :: QV1UU1VO &-KA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,733,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,733,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,733,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1278-0263 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4216 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated) No. of Female Employees: 7 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H310-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P302 + P350-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R23/25;R27;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AP0700000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

[ HS Code ]:
29171990

Precursor & DownStream

Precursor

DownStream

diethylbut-2-indioat
succinic acid-d4
Bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylicacid
bicyclo[2.2.1]hepta-2,5-diene-3-carboxylic acid
1,4-Dioxyl radical
(E)-2,3-Dibromo-2-butenedioic acid

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

Mol. Divers. 17(1) , 55-61, (2013)

A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of POCl(3) was used as a highly efficient and practical approach for the synthesis of ...

Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis.

Bioorg. Med. Chem. Lett. 21 , 7273-6, (2011)

Efficient and rapid synthesis of 1,2,3-triazole derivatives has been achieved via Huisgen's 1,3-dipolar cycloaddition between alkyl/arylazides and diethyl/dimethyl acetylenedicarboxylate in excellent ...

Synthesis of symmetrical and unsymmetrical diarylalkynes from propiolic acid using palladium-catalyzed decarboxylative coupling.

J. Org. Chem. 75(18) , 6244-51, (2010)

Symmetrical diarylalkynes were obtained from propiolic acid (or 2-butynedioic acid) and aryl halides in good yields. The optimized reaction conditions were 2.0 equiv of aryl halide, 1.0 equiv of propi...

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