2-(4-Benzylphenoxy)-N,N-diethylethylamine hydrochloride

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Names

[ CAS No. ]:
92981-78-7

[ Name ]:
2-(4-Benzylphenoxy)-N,N-diethylethylamine hydrochloride

[Synonym ]:
Diaethyl-[2-(4-benzyl-phenoxy)-aethyl]-amin,Hydrochlorid
N,N-diethyl-2-[(4-phenylmethyl)phenoxy]ethanamine hydrochloride
Tesmilifene hydrochloride
N,N-diethyl-2-<4-(phenylmethyl)phenoxy>-ethaneamine * HCl
[2-(4-Benzoylbenzoyloxy)ethyl](dimethyl)[2-(myristoyloxy)-ethyl]ammoniumbromid
2-(4-benzoylbenzoyl)oxyethyl-dimethyl-(2-tetradecanoyloxyethyl)azanium bromide
Ethanaminium,2-((4-benzoylbenzoyl)oxy)-N,N-dimethyl-N-(2-((1-oxotetradecyl)oxy)ethyl)-,bromide
diethyl-[2-(4-benzyl-phenoxy)-ethyl]-amine,hydrochloride
[2-(4-benzylphenoxy)ethyl]diethylammonium chloride

Chemical & Physical Properties

[ Boiling Point ]:
397ºC at 760 mmHg

[ Molecular Formula ]:
C6H12N2NaO12P4Sm----

[ Molecular Weight ]:
603.97300

[ Flash Point ]:
116.8ºC

[ Exact Mass ]:
603.84600

[ PSA ]:
280.51000

[ LogP ]:
1.76460

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Benzylphenol
  • 2-Chloro-N,N-diethylethanamine
  • 2-Diethylaminoethylchloride Hydrochloride

DownStream

Articles

Enhancement of antitumour activity of cisplatin by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine. HCl in human ovarian cancer cells with intrinsic or acquired resistance to cisplatin.

Eur. J. Cancer 33(1) , 122-8, (1997)

This study was designed to the elucidate sensitising effects of the intracellular histamine antagonist, N,N-diethyl-2[4-(phenylmethyl)phenoxy] ethanamine HCl (DPPE) on the antitumour activity of cis-d...

Effect of alpha-FMH and DPPE on colony-forming properties of human peripheral progenitor cells.

Curr. Med. Chem. 9(14) , 1349-57, (2002)

Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. The effect of histi...

Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats.

J. Pharm. Pharmacol. 62(8) , 1084-8, (2010)

It has been reported that docetaxel is a P-glycoprotein substrate and is metabolized via the cytochrome P450 (CYP) 3A subfamily in rats. Tesmilifene is a substrate of the CYP3A subfamily and is an inh...


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Related Compounds

  • 1h-Indole-5-carboxamide,n-ethyl-2,3-dihydro-n-[2-[(1-methylethyl)amino]-2-oxoethyl]-
  • 1h-Indole-5-carboxamide,n-[(2-chlorophenyl)methyl]-2,3-dihydro-n-methyl-
  • 1h-Indole-5-carboxamide,n-[(4-bromophenyl)methyl]-2,3-dihydro-n-methyl-
  • 1-(4-ethyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)prop-2-en-1-one
  • 1-[Difluoro(phenyl)methyl]cyclobutan-1-amine
  • N-(cyclohexylmethyl)-N-cyclopropylprop-2-enamide
  • {1-[Difluoro(phenyl)methyl]cyclopropyl}methanamine
  • 5-((2-Methylbenzyl)thio)pentan-2-one
  • 1-[2-(2,6-Difluorophenyl)ethyl]cyclopropan-1-amine
  • 4-((Cyclopropylamino)methyl)tetrahydro-2H-pyran-4-ol
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