N,N-Diethyl-1,4-phenylenediamine

Names

[ CAS No. ]:
93-05-0

[ Name ]:
N,N-Diethyl-1,4-phenylenediamine

[Synonym ]:
EINECS 202-214-1
4-N,4-N-diethylbenzene-1,4-diamine
MFCD00007861

Chemical & Physical Properties

[ Density]:
0.988 g/mL at 25 °C(lit.)

[ Boiling Point ]:
115-116 °C5 mm Hg(lit.)

[ Melting Point ]:
19-21 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₆N₂

[ Molecular Weight ]:
164.24700

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
164.13100

[ PSA ]:
29.26000

[ LogP ]:
2.69620

[ Index of Refraction ]:
n20/D 1.571(lit.)

[ Storage condition ]:
Freezer

[ Stability ]:
Stability Air and light sensitive. Incompatible with strong oxidizing agents, strong acids.

[ Water Solubility ]:
<0.1 g/100 mL at 19 ºC

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SS9275000

CHEMICAL NAME :: p-Phenylenediamine, N,N-diethyl-

CAS REGISTRY NUMBER :: 93-05-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C10-H16-N2

MOLECULAR WEIGHT :: 164.28

WISWESSER LINE NOTATION :: ZR DN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

DOSE/DURATION :: 73 ug/kg

TOXIC EFFECTS :: Blood - hemorrhage Skin and Appendages - primary irritation (after topical exposure) Skin and Appendages - dermatitis, allergic (after topical exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - muscle weakness

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Skin and Appendages - hair

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R34

[ Safety Phrases ]:
S26-S36-S45

[ RIDADR ]:
UN 2922 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
SS9275000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29215190

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

n,n-diethyl-4-nitroaniline
N,N-Diethyl-4-nitrosoaniline
N,N-diethyl-4-(phenylazo)-benzeneamine
1-Fluoro-4-nitrobenzene
4-(N,N-diethylamino)-N-(1-methylquinolinio-2-methylidene) aniline iodide
4,4'-Bis(diethylamino)azobenzene
N,N-Diethyl-1,4-phenylenediamine
4'-methoxy-4-diethylaminoazobenzene
4-((4-(diethylamino)phenyl)diazenyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

DownStream

4-(diethylamino)benzenediazonium tetrafluoroborate
N-[4-(diethylamino)phenyl]benzenesulfonamide
1,4-benzoquinone imine
4-azido-N,N-diethylaniline
diethyl-(4-iminocyclohexa-2,5-dien-1-ylidene)azanium
N,N-Diethyl-1,4-phenylenediamine
4-DIETHYLAMINOPHENYL ISOTHIOCYANATE
4-N,4-N-diethyl-1-N-(2-nitro-1-benzothiophen-3-yl)benzene-1,4-diamine
1-amino-3-[4-(diethylamino)phenyl]thiourea
N,N-Dimethylaniline

Customs

[ HS Code ]: 29215190

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N,N-DIETHYL-1,4-PHENYLENEDIAMINE OXALATE
N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE
N,N-diethyl-1,4-phenylenediamine dihydrochloride
N,N-Diethyl-1,4-benzenediamine sulfate (1:1)
N,N-diethyl-1,4-dimethylcyclohex-3-ene-1-carboxamide
N,N-diethyl-1,4-dihydropyridine-3-carboxamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
1,1-Dimethylethyl 4-[[[(4-bromophenyl)amino]carbonyl]methylamino]-1-piperidinecarboxylate
4-(4-(4-(4-((5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
Isopropyl 3,5-dibromo-4-hydroxybenzoate