4-(2-Naphthylamino)phenol

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Names

[ CAS No. ]:
93-45-8

[ Name ]:
4-(2-Naphthylamino)phenol

[Synonym ]:
4-(2-Naphthylamino)phenol
N-(p-Hydroxyphenyl)-2-naphthylamine
Phenol, 4-(2-naphthalenylamino)-
4-(naphthalen-2-ylamino)phenol
Phenol, p- (2-naphthylamino)-
N-(4-Hydroxyphenyl)-2-naphthylamine
Phenol, 4- (2-naphthalenylamino)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
424.4±20.0 °C at 760 mmHg

[ Melting Point ]:
139-142ºC(lit.)

[ Molecular Formula ]:
C16H13NO

[ Molecular Weight ]:
235.281

[ Flash Point ]:
173.1±12.4 °C

[ Exact Mass ]:
235.099716

[ PSA ]:
32.26000

[ LogP ]:
4.05

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.734

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM1750000
CHEMICAL NAME :
Phenol, p-(2-naphthylamino)-
CAS REGISTRY NUMBER :
93-45-8
BEILSTEIN REFERENCE NO. :
1642793
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H13-N-O
MOLECULAR WEIGHT :
235.30
WISWESSER LINE NOTATION :
L66J CMR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(1-3),183,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(1-3),183,1966 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
31200 mg/kg/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(2),25,1966

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-36/37/38-40

[ Safety Phrases ]:
26-36/37/39-45

[ RTECS ]:
SM1750000

[ HS Code ]:
2922299090

Synthetic Route

Precursor & DownStream

Precursor

  • N-β-Naphthyl-1,4-benzoquinone monoimine
  • 4-Aminophenol
  • 2-Naphthol
  • 4-Chloroaniline
  • p-Anisidine
  • 4-Bromoaniline
  • Naphthalen-2-amine
  • 3-Hydroxy-2-naphthoic acid

DownStream

  • 2-Methoxynaphthalene
  • 2-Naphthalenamine,N-(4-methoxyphenyl)-

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds

  • (2E)-4-(2-Naphthylamino)-4-oxo-2-butenoic acid
  • Sulfamide, 2-naphthalenyl- (9CI)
  • 4-(2-isopropyloxyethoxy)phenol
  • 4-(2-Bromoethyl)phenol
  • 4-(2-methoxyphenyl)phenol
  • 4-(2-hydroxyethoxy)phenol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (2E)-3-[3-Bromo-5-ethoxy-4-(2-methoxy-2-oxoethoxy)phenyl]acrylic acid
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 1-Benzyl-3-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]-1-methylurea
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine