Creosol

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Names

[ CAS No. ]:
93-51-6

[ Name ]:
Creosol

[Synonym ]:
Homoguaiacol
p-Cresol,2-methoxy
creosol
2-methoxy-4-cresol
2-Methoxy-p-cresol
EINECS 202-252-9
p-Methylguaiacol
p-Creosol
4-Methylguaiacol
3-methoxy-4-hydroxytoluene
MFCD00002378
2-Methoxy-4-methylphenol
Phenol, 2-methoxy-4-methyl-
Phenol,2-methoxy-4-methyl
2-methoxy-4-methyl-phenol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
220.0±0.0 °C at 760 mmHg

[ Melting Point ]:
5 °C(lit.)

[ Molecular Formula ]:
C8H10O2

[ Molecular Weight ]:
138.164

[ Flash Point ]:
99.4±0.0 °C

[ Exact Mass ]:
138.068085

[ PSA ]:
29.46000

[ LogP ]:
1.65

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.531

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GP1755000
CHEMICAL NAME :
p-Cresol, 2-methoxy-
CAS REGISTRY NUMBER :
93-51-6
BEILSTEIN REFERENCE NO. :
1862340
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H10-O2
MOLECULAR WEIGHT :
138.18
WISWESSER LINE NOTATION :
QR D1 BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
740 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
76 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30196 mg/kg/40D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1512 No. of Facilities: 14 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 1639 (estimated) No. of Female Employees: 276 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
2810

[ WGK Germany ]:
3

[ RTECS ]:
GP1755000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
29095090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Vanillin
  • Vanillic acid
  • Vanillyl alcohol
  • 2-Bromo-4-methylphenol
  • Sodium Methylate
  • 2-methoxy-4-methylphenyl propionate
  • 2-methoxy-para-tolyl acetate
  • 2-(2-methoxy-4-methyl-phenoxy)acetic acid
  • 2-Methylanisole

DownStream

  • Citraconic acid
  • UNII:H1547KG7UZ
  • 2-hydroxy-2-methyl-butanedioic acid
  • Malonic acid
  • (2Z,4E)-3-methyl-2,4-hexadienedioic acid
  • Oxalic acid
  • 1,2-Dimethoxy-4-methylbenzene
  • Vanillyl alcohol
  • Vanillic acid
  • methyl vanillyl ether

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

In chemico evaluation of prohapten skin sensitizers: behavior of 2-methoxy-4-(¹³C)methylphenol in the peroxidase peptide reactivity assay (PPRA) as an alternative to animal testing.

Toxicol. Lett. 218(3) , 266-72, (2013)

In chemico methods, based on the assessment of a hapten's reactivity toward peptides, have been proposed as alternative methods for the assessment of the skin sensitizing potential of chemicals. Howev...

Rapid discrimination and characterization of vanilla bean extracts by attenuated total reflection infrared spectroscopy and selected ion flow tube mass spectrometry.

J. Food Sci. 77(3) , C284-92, (2012)

Vanilla beans have been shown to contain over 200 compounds, which can vary in concentration depending on the region where the beans are harvested. Several compounds including vanillin, p-hydroxybenza...

Binding of alkyl- and alkoxy-substituted simple phenolic compounds to human serum proteins.

Res. Commun. Mol. Pathol. Pharmacol. 107(1-2) , 167-73, (2000)

Wood creosote, primarily a mixture of simple alkyl- and/or alkoxy-substituted phenolic compounds with closely related structures, has long been used as an oral antidiarrheal agent. The use of wood cre...


More Articles

Related Compounds

  • Creosol-d4
  • 5-Ethyl-creosol
  • 5.6-dinitro-creosol
  • Creosol, 3,5-dinitro-
  • Creosol,5-amino- (5CI)
  • 1-[(3-Phenoxyphenyl)methyl]cyclopropan-1-amine
  • 1-(4,5-Difluoro-2-nitrophenyl)cyclopentan-1-amine
  • 1-(2,6-Dimethoxy-4-methylphenyl)-2-methylpropan-2-amine
  • 4-Amino-3-hydroxy-3-(3-methylcyclohexyl)butanoic acid
  • ethyl 5-{5-oxaspiro[2.4]heptan-1-yl}-1H-1,2,3-triazole-4-carboxylate
  • 1-[(3-methoxyphenyl)methyl]-4-{4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}piperazin-2-one
  • 2-[(2S)-1-[(2RS,3SR)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolane-2-carbonyl]piperidin-2-yl]acetic acid
  • 1-tert-butyl 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl) 4-(methoxymethyl)piperidine-1,4-dicarboxylate
  • 1-tert-butyl 2,6-dimethyl (2R,4s,6S)-4-hydroxypiperidine-1,2,6-tricarboxylate
  • 3,3-Difluoro-3-[2-(pyrrolidin-1-yl)pyridin-3-yl]propan-1-amine