2-Vinyloxirane

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Names

[ CAS No. ]:
930-22-3

[ Name ]:
2-Vinyloxirane

[Synonym ]:
2-Vinyloxirane
3,4-EPOXY-1-BUTENE
EINECS 213-210-4
Oxirane, 2-ethenyl-
2-ethenyloxirane
MFCD00005149
UNII:478ERR5NKR

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
70.0±9.0 °C at 760 mmHg

[ Melting Point ]:
-135ºC

[ Molecular Formula ]:
C4H6O

[ Molecular Weight ]:
70.090

[ Flash Point ]:
-50.0±0.0 °C

[ Exact Mass ]:
70.041862

[ PSA ]:
12.53000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
142.6±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EM7350000
CHEMICAL NAME :
1-Butene, 3,4-epoxy-
CAS REGISTRY NUMBER :
930-22-3
LAST UPDATED :
199801
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C4-H6-O
MOLECULAR WEIGHT :
70.10
WISWESSER LINE NOTATION :
T3OTJ B1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
168 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
492 gm/kg/41W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Mutation in mammalian somatic cells

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
625 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Highlyflammable;Xn:Harmful;

[ Risk Phrases ]:
R11;R40

[ Safety Phrases ]:
S16-S36/37-S45

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
EM7350000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2910900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • butadiene
  • 2-BUTENE-1,4-DIOL
  • Peracetic acid
  • acetic acid,4-bromobut-2-en-1-ol
  • acetic acid,4-chlorobut-2-en-1-ol
  • Methanol
  • 2,2'-Bioxirane,(2R,2'S)-rel-
  • 1,2-epoxy-4-bromobutane
  • Perbenzoic acid
  • Peroxide, diacetyl

DownStream

  • 1-(1-hydroxybut-3-en-2-yl)pyrimidin-2-one
  • 4-Vinyl-1,3-dioxolan-2-one
  • 3-Phenylpropene-3-ol
  • (Z)-4-Phenyl-2-buten-1-ol
  • 4-Phenyl-2-buten-1-ol
  • 1,2-EPOXYBUTANE
  • Crotonaldehyde
  • Methyl n-propyl ether
  • 3-methoxypropene
  • Butyraldehyde

Customs

[ HS Code ]: 2910900090

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

In vivo doses of butadiene epoxides as estimated from in vitro enzyme kinetics by using cob(I)alamin and measured hemoglobin adducts: an inter-species extrapolation approach.

Toxicol. Appl. Pharmacol. 281(3) , 276-84, (2014)

1,3-Butadiene (BD) is a rodent and human carcinogen. In the cancer tests, mice have been much more susceptible than rats with regard to BD-induced carcinogenicity. The species-differences are dependen...

Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells.

Chem. Biol. Interact. 166(1-3) , 207-18, (2007)

The carcinogenicity of 1,3-butadiene (BD) is related to its bioactivation to several DNA-reactive metabolites; accumulating evidence suggests that the stereochemistry of these BD intermediates may pla...

Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[(14)C]-butadiene.

Chem. Biol. Interact. 147(2) , 195-211, (2004)

Male Sprague-Dawley rats and B6C3F1 mice were exposed to either a single 6h or a multiple (5) daily (6h) nose-only dose of 1,3-[2,3-(14)C]-butadiene at exposure concentrations of nominally 1, 5 or 20 ...


More Articles

Related Compounds

  • 2-phenyl-2-vinyloxirane
  • 2-Methyl-2-vinyloxirane
  • cis-1-phenyl-2-vinyloxirane
  • trans-1-phenyl-2-vinyloxirane
  • cis-1-Cyclohexyl-2-vinyloxirane
  • 3-phenyl-2-(trifluoromethyl)-2-vinyloxirane
  • 4-Cyano-3-formyl-5-hydroxybenzenesulfonyl chloride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-Bromo-6-methylimidazo[2,1-b]thiazole
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine