N-Methylmaleimide

Names

[ CAS No. ]:
930-88-1

[ Name ]:
N-Methylmaleimide

[Synonym ]:
1H-Pyrrole-2,5-dione, 1-methyl-
EINECS 213-226-1
MFCD00005508
N-Methylmaleimide
1-methylpyrrole-2,5-dione
1-Methyl-1H-pyrrole-2,5-dione
N-Methyl-2,5-pyrroledione

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
194.1±9.0 °C at 760 mmHg

[ Melting Point ]:
94-96 °C(lit.)

[ Molecular Formula ]:
C₅H₅NO₂

[ Molecular Weight ]:
111.099

[ Flash Point ]:
84.4±11.1 °C

[ Exact Mass ]:
111.032028

[ PSA ]:
37.38000

[ LogP ]:
0.15

[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.530

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON5600000

CHEMICAL NAME :: Maleimide, N-methyl-

CAS REGISTRY NUMBER :: 930-88-1

BEILSTEIN REFERENCE NO. :: 0108550

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H5-N-O2

MOLECULAR WEIGHT :: 111.11

WISWESSER LINE NOTATION :: T5VNVJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 9,344,1957

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R20/21;R25;R34;R43

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 1759 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
ON5600000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Maleic anhydride
Methylamine hydrochloride
trimethyl-(1-methyl-5-trimethylsilyloxypyrrol-2-yl)oxysilane
methylamine
2-Butenoic acid,4-(methylamino)-4-oxo-, (2Z)-
N-Methylsuccinimide
1-Methylpyrrole
acetic acid

DownStream

3-benzyl-1-methylpyrrolidine-2,5-dione
Benzylamine
5-Hydroxy-N-methyl-2-pyrrolidinone
Biphenylene
3a,4,9,9a-tetrahydro-2-methyl-4,9-diphenyl-4,9-epoxybenzo[f]isoindole-1,3-dione
1,2-dibenzoylbenzene
Phensuximide
4-Amino-n-methylphthalimide

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway.

PLoS Genet. 12 , e1005773, (2016)

Pathogen expulsion from the gut is an important defense strategy against infection, but little is known about how interaction between the intestinal microbiome and host immunity modulates defecation. ...