5-amino-2H-isoquinolin-1-one,hydrochloride

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Names

[ CAS No. ]:
93117-07-8

[ Name ]:
5-amino-2H-isoquinolin-1-one,hydrochloride

[Synonym ]:
5-AIQ hydrochloride
5-aminoisoquinolin-1-one hydrochloride
5-Aminoisoquinolin-1(2H)-one hydrochloride
5-Aminoisoquinolinone hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
481ºC at 760 mmHg

[ Molecular Formula ]:
C9H9ClN2O

[ Molecular Weight ]:
196.63400

[ Flash Point ]:
244.7ºC

[ Exact Mass ]:
196.04000

[ PSA ]:
59.14000

[ LogP ]:
2.90580

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Nitro-1(2H)-isoquinolinone
  • 1-Chloro-5-nitroisoquinoline
  • 1-Chloroisoquinoline

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

PLoS ONE 8(2) , e55883, (2013)

Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here,...

Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

Biochem. Biophys. Res. Commun. 387 , 646-50, (2009)

Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidati...

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006)

Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in m...


More Articles

Related Compounds

  • 5-AMINO-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE HYDROCHLORIDE
  • 5-(piperidin-4-ylamino)-2H-isoquinolin-1-one,hydrochloride
  • 6-amino-1,2-dihydro-7-methyl-2-<<5(4)-methyl-4(5)-imidazolyl>methyl>-1-oxoisoquinoline dihydrochloride
  • Hydroxy Fasudil Hydrochloride
  • 6,8-dihydroxy-2H-isoquinolin-1-one,hydrochloride
  • SAR407899 (hydrochloride)
  • 3-(4-amino-2-oxopyrrolidin-1-yl)-N-(propan-2-yl)azetidine-1-carboxamide
  • 1-[2-(2-aminoethyl)-4,5-dihydro-1H-imidazol-1-yl]-2-cyclopropylethan-1-one
  • N-[(6-aminopyridin-2-yl)methyl]propanamide
  • N-[6-(aminomethyl)pyridin-2-yl]-2,3-dimethylbutanamide
  • 4'-Bromo-2'-fluoro-[1,1'-biphenyl]-3-carbaldehyde
  • 1-[4-(Aminomethyl)-4-(trifluoromethyl)piperidin-1-yl]-2-methylpentan-1-one
  • 6-(2-aminoethyl)-N-(3-methylbutan-2-yl)-1,2,3,4-tetrahydroquinoline-1-carboxamide
  • 1-{9-Amino-1-oxa-4-azaspiro[5.5]undecan-4-yl}-3-methoxypropan-1-one
  • 4-amino-N-(2-methoxyethyl)-5-(trifluoromethyl)azepane-1-carboxamide
  • 1-[2-(aminomethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]-2-cyclopropylethan-1-one
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