Conantokin G

[ Molecular Formula ]:
C₈₈H₁₃₈N₂₆O₄₄

[ Molecular Weight ]:
2264.19000

[ Exact Mass ]:
2262.94000

[ PSA ]:
1225.52000

[ Storage condition ]:
-20°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

Curr. Drug Targets. CNS Neurol. Disord. 4(2) , 143-51, (2005)

Glutamate is the main excitatory neurotransmitter in the central nervous system and it plays a significant role not only in synaptic transmission but also in acute and chronic neuropathologies includi...

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs.

Epilepsy Res. 59(1) , 13-24, (2004)

The N-methyl-D-aspartate (NMDA) receptor-gated ion channel is comprised of at least one NR1 subunit and any of four NR2 subunits (NR2A-D). The NR2 subunit confers different pharmacological and kinetic...

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

Neuropharmacology 57(2) , 127-36, (2009)

The conantokins are short, naturally occurring peptides that inhibit ion flow through N-methyl-d-aspartate receptor (NMDAR) channels. One member of this peptide family, conantokin-G (con-G), shows hig...

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