Oprozomib (ONX 0912)

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Names

[ Name ]:
Oprozomib (ONX 0912)

[Synonym ]:
ONX-0912
4,5-Anhydro-1,2-dideoxy-4-methyl-2-({O-methyl-N-[(2-methyl-1,3-thiazol-5-yl)carbonyl]-L-seryl-O-methyl-L-seryl}amino)-1-phenyl-D-erythro-pent-3-ulose
QC-9273
PR-047
ONX 0912
D-erythro-3-Pentulose, 4,5-anhydro-1,2-dideoxy-4-C-methyl-2-[[O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-L-seryl]amino]-1-phenyl-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
849.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₂N₄O₇S

[ Molecular Weight ]:
532.609

[ Flash Point ]:
467.8±34.3 °C

[ Exact Mass ]:
532.199158

[ PSA ]:
186.96000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one 2,2,2-trifluoroacetate
2-Methyl-5-thiazolecarboxylic acid
(S)-2-amino-3-methoxy-N-((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)propanamide 2,2,2-trifluoroacetate
Ethyl 2-methylthiazole-5-carboxylate