2,4'-dichloroacetophenone

Names

[ CAS No. ]:
937-20-2

[ Name ]:
2,4'-dichloroacetophenone

[Synonym ]:
2,4'-dichloroacetophenone
Ethanone, 2-chloro-1-(4-chlorophenyl)-
MFCD00018926
2-Chloro-1-(4-chlorophenyl)ethanone
EINECS 213-323-9

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
270.0±0.0 °C at 760 mmHg

[ Melting Point ]:
100-102 °C(lit.)

[ Molecular Formula ]:
C₈H₆Cl₂O

[ Molecular Weight ]:
189.039

[ Flash Point ]:
119.1±21.0 °C

[ Exact Mass ]:
187.979568

[ PSA ]:
17.07000

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

dimethylsulfoxonium 2-(4-chlorophenyl)-2-oxoethylide
1-(4-Chlorophenyl)ethanone
1-chloro-2-(4-chlorophenyl)ethyne
Diazald
4-Chlorobenzoyl chloride
Chloroacetyl chloride
Chlorobenzene
1-(4-Chlorophenyl)ethanol
1-(4-chlorophenyl)-2-iodoethanone
Benzyl alcohol, p-chloro-.alpha.-(trichloromethyl)-

DownStream

2-Amino-1-(4-chlorophenyl)ethanone hydrochloride
2-(4-Chlorophenyl)-2-oxoethyl acetate
1-(4-CHLORO-PHENYL)-2-[2-(4-CHLORO-PHENYL)-2-OXO-ETHYLSULFANYL]-ETHANONE
Dibenzyl disulfide
S-(+)-2-octanol
(R)-(−)-2-Octanol
(S)-2-chloro-1-(4-chlorophenyl)ethanol
1-(4-Chlorophenyl)ethanone
4-Chlorophenylacetic acid

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta6-arene/TsDPEN-ruthenium(II) complexes.

Org. Lett. 9(2) , 255-257, (2007)

Asymmetric hydrogenation of various alpha-chloro aromatic ketones with Ru(OTf)(TsDPEN)(eta6-arene) (TsDPEN = N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine) produces the chiral chlorohydrins in up ...

Purification and characterization of a yeast carbonyl reductase for synthesis of optically active (R)-styrene oxide derivatives.

Biosci. Biotechnol. Biochem. 69(1) , 79-86, (2005)

Optically active styrene oxide derivatives are versatile chiral building blocks. Stereoselective reduction of phenacyl halide to chiral 2-halo-1-phenylethanol is the key reaction of the most economica...

Direct Investigation of Covalently Bound Chlorine in Organic Compounds by Solid-State ³⁵Cl NMR Spectroscopy and Exact Spectral Line-Shape Simulations. Perras FA and Bryce DL.

Angew. Chem. Weinheim Bergstr. Ger. 124(11) , 4303-4306, (2012)

2'-Amino-2,4'-dichloroacetophenone
2-bromo-2',4'-dichloroacetophenone
2-Amino-2',4'-dichloroacetophenone
2-Bromo-2',4'-dichloroacetophenone
2-(4'-iodophenyl)benzoxazole
2-(4'-Trifluoromethyl)phenyl-2-propyl cation
(4-(2-Methoxyethoxy)phenyl)(thiophen-3-yl)methanol
N-[(6-bromo-2-pyridinyl)-3-thienylmethylene]-2-methyl-2-propanesulfinamide
6-Bromo-n-methoxy-n-methyl-5-morpholinopyridine-2-carboxamide
6-[4-(3-Hydroxypropoxy)phenyl]-6-(3-thienyl)-2,4-piperidinedione
[4-(3-Methoxypropoxy)phenyl]-3-thienylmethanone
6-(4-Cyclopropylphenyl)-6-(3-thienyl)-2,4-piperidinedione
N-methoxy-n-methyl-3-[(tetrahydro-2h-pyran-4-yl)oxy]benzamide
5,6-Dihydro-4-hydroxy-6-(2-naphthalenyl)-6-(3-thienyl)-2(1h)-pyridinone
Methyl 5-amino-5-(6-bromopyridin-2-yl)-3-oxo-5-(thiophen-3-yl)pentanoate
2-(1-Acetyl-4-methyl-3-oxopiperazin-2-yl)acetic acid