Benzyl(methyl)nitrosamine

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Names

[ CAS No. ]:
937-40-6

[ Name ]:
Benzyl(methyl)nitrosamine

[Synonym ]:
N-Nitrosobenzylmethylamine
Nitrosobenzylmethylamine
N-Nitrosomethylbenzylamine
Benzylamine,N-methyl-N-nitroso
N-Methyl-N-nitrosobenzylamine
N-nitroso-N-benzylmethylamine
PhCH2N(NO)Et
Benzyl(methyl)nitrosamine
N-methyl-n-benzylnitrosamine
N-Methyl-N-nitroso-benzenemethanamine
PhCH2N(NO)Me
N-Nitroso-N-methylbenzylamine
Methylbenzylnitrosamine

Chemical & Physical Properties

[ Density]:
1.03g/cm3

[ Boiling Point ]:
298.2ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₀N₂O

[ Molecular Weight ]:
150.17800

[ Flash Point ]:
134.1ºC

[ Exact Mass ]:
150.07900

[ PSA ]:
32.67000

[ LogP ]:
1.79980

[ Index of Refraction ]:
1.528

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP6300000

CHEMICAL NAME :: Benzylamine, N-methyl-N-nitroso-

CAS REGISTRY NUMBER :: 937-40-6

BEILSTEIN REFERENCE NO. :: 1841634

LAST UPDATED :: 199612

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C8-H10-N2-O

MOLECULAR WEIGHT :: 150.20

WISWESSER LINE NOTATION :: ONN1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg/20W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37500 ug/kg/15W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg/86W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/69W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg/81W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 116 mg/kg/22W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg/29W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg/8W

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 6,1731,1985

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-Methylbenzylamine
dimethylbenzylamine
dibemethine
N-Benzylcyclopropanamine
Benzaldehyde
potassium methyl(nitroso)amide
(Iodomethyl)benzene
potassium,benzyl(nitroso)azanide
methyl iodide

DownStream

N-Methylbenzylamine
N-Benzylidenemethanamine
Hydrazine,1-methyl-1-(phenylmethyl)-
Benzaldehyde
benzoic acid
Benzyl alcohol

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

benzyl methyl(2-piperidin-1-ylethyl)carbamate
benzyl(methyl)sulfamoyl chloride(SALTDATA: FREE)
Benzyl-(methyl)-phenylsulfonium
Benzyl methyl[(3S)-3-pyrrolidinyl]carbamate
[[benzyl(methyl)amino]-phosphonomethyl]phosphonic acid
benzyl(methyl)carbamic chloride
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxyquinazoline-6-carbaldehyde
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-3-ol hydrochloride
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
[4-(Trifluoroprop-1-yn-1-yl)phenyl]methanol
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde