GSK690693
Suppliers
Names
[ CAS No. ]:
937174-76-0
[ Name ]:
GSK690693
[Synonym ]:
4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol
(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol
3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-
GSK690693
cc-44
4-{2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol
GSK-690693
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
683.8±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H27N7O3
[ Molecular Weight ]:
425.484
[ Flash Point ]:
367.3±34.3 °C
[ Exact Mass ]:
425.217529
[ PSA ]:
137.14000
[ LogP ]:
4.34
[ Appearance of Characters ]:
white to beige
[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C
[ Index of Refraction ]:
1.683
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble5mg/mL (clear solution)
MSDS
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Hazard Codes ]:
T
[ Risk Phrases ]:
25
[ Safety Phrases ]:
45
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Pathol. 234(2) , 152-63, (2014)
Morgana/CHP-1 is a ubiquitously expressed protein able to inhibit ROCK II kinase activity. We have previously demonstrated that morgana haploinsufficiency leads to multiple centrosomes, genomic instab...
Mol. Cancer Ther. 14 , 1805-15, (2015)
mTOR is aberrantly activated in hepatocellular carcinoma (HCC) and plays pivotal roles in tumorigenesis and chemoresistance. Rapamycin has been reported to exert antitumor activity in HCC and sensitiz...
PLoS ONE 10 , e0132880, (2015)
Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysregulated in a variety of cancers and considered to be an appealing therapeutic target. It has been pro...