2-(p-Tolyl)propanoic acid

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Names

[ CAS No. ]:
938-94-3

[ Name ]:
2-(p-Tolyl)propanoic acid

[Synonym ]:
MFCD01111378
Benzeneacetic acid, α,4-dimethyl-
UNII:1635C8OCXW
2-p-Tolylpropanoic acid
2-(4-Methylphenyl)propionic acid
Methylphenylpropinoic acid
2-(4-Methylphenyl)propanoic acid
4-methyl-hydratropic acid
2-(4-methylphenyl)propionicacid
p-Methylhydratropic acid.
IBUPROFEN IMP D
IBUPROFEN IMPURITY D
Ibuprofen Impurity 4

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
278.0±9.0 °C at 760 mmHg

[ Melting Point ]:
37-42 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₂O₂

[ Molecular Weight ]:
164.201

[ Flash Point ]:
175.2±13.9 °C

[ Exact Mass ]:
164.083725

[ PSA ]:
37.30000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Methylstyrene
carbon monoxide
ethyl 2-(p-tolyl)propanoate
2-Hydroxy-2-(p-tolyl)propanoic acid
Methyl 2-(2-methylphenyl)propanoate
Tolylacetic acid
methyl iodide
Formic Acid
Oxalic acid
1-chloro-1-p-tolyl-acetone

DownStream

Terephthalic acid
4-Carboxy-α-methylbenzeneacetic Acid
Methyl 2-(2-methylphenyl)propanoate
methyl 2-(2,4-dimethylphenyl)acetate
Benzeneethanol, .beta.,4-dimethyl-
2-methyl-2-(4-methylphenyl)cyclopentan-1-one

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

The enantioselective metabolism of 4-isopropenyltoluene in rabbits.

Biol. Pharm. Bull. 17(11) , 1441-5, (1994)

4-Isopropenyltoluene (8) was administered orally to rabbits and the following four optically active metabolites, 2-(p-tolyl)propanoic acid (10), p-(1-carboxyethyl)benzoic acid (11), 2-hydroxy-2-(p-tol...

Chemical Studies on Azalomycins. III. Alkaline Degradation of Azalomycin-B. Tukahashi S and 0kki E.

Chem. Pharm. Bull. 15(11) , 1726-1732, (1967)

Pinonic Acid-a Promising Chemical Raw Material. Hedrick G and Lawrence R.

Ind. Eng. Chem. Fundam. 52(10) , 853-856, (1960)

2-methyl-2-(p-tolyl)propanoic acid
3-Amino-2-(p-tolyl)propanoic acid HCl
2-hydroxy-3-phenyl-2-(p-tolyl)propanoic acid
2-((tert-Butoxycarbonyl)amino)-3-(p-tolyl)propanoic acid
(S)-2-acetamido-3-(p-tolyl)propanoic acid
(S)-2-(butylsulfonamido)-3-(p-tolyl)propanoic acid
2-(1H-benzimidazol-2-yl)-3-(4-methylphenyl)propanethioamide
2-(1H-1,3-benzodiazol-2-yl)-3-(4-methoxyphenyl)propanethioamide
1-(3-Ethylmorpholin-4-yl)prop-2-en-1-one
3-(2,5-dimethylphenyl)-10-methoxy-2-methyl-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5]oxadiazocine-4(3H)-thione
3-(2-chlorophenyl)-10-ethoxy-2-methyl-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5]oxadiazocine-4(3H)-thione
6-methyl-3-phenyl-2-thioxo-5-((3-(trifluoromethyl)benzyl)thio)-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one
6-methyl-5-((2-methylbenzyl)thio)-2-thioxo-3-(p-tolyl)-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one
2-(1H-benzimidazol-2-yl)-3-(3,4-dimethoxyphenyl)propanethioamide
2-(4-Amino-3-methylphenoxy)benzonitrile
2-Methyl-4-(pyridin-4-yloxy)aniline