Fluvastatin

Suppliers

Names

[ CAS No. ]:
93957-54-1

[ Name ]:
Fluvastatin

[Synonym ]:
(3S,5R,6E)-7-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
UNII:4L066368AS
fluvastatin
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)-
FLUVASTATIN NA
Lipaxan
MFCD00929076
(3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
Lescol
(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
(3S,5R,6E)-7-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
(±)-(3R*,5S*,6E)-7-[3-(p-fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3S,5R,6E)-
FLUVASTATIN SODIUM
Primexin

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
681.8±55.0 °C at 760 mmHg

[ Melting Point ]:
194-197ºC

[ Molecular Formula ]:
C24H26FNO4

[ Molecular Weight ]:
411.466

[ Flash Point ]:
366.1±31.5 °C

[ Exact Mass ]:
411.184601

[ PSA ]:
82.69000

[ LogP ]:
3.62

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.587

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MJ9675050
CHEMICAL NAME :
6-Heptenoic acid, 7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl )- 3,5-dihydroxy-, (R*,S*-(E))-(+-)-
CAS REGISTRY NUMBER :
93957-54-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C24-H26-F-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
11648 mg/kg/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
REFERENCE :
LETRET Lens and Eye Toxicity Research. (Marcel Dekker, Journal Customer Service, POB 5017, Monticello, NY 12701) V.6n.1-2- 1989- Volume(issue)/page/year: 7,563,1990

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R42/43:May cause sensitization by inhalation and skin contact .

[ Safety Phrases ]:
S23-S26-S37

[ RIDADR ]:
UN 3272 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

Synthetic Route

Precursor & DownStream

Precursor

  • SRI 62320

DownStream

  • FLUVASTATIN LACTONE

Related Compounds

  • no-fluvastatin
  • Fluvastatinsodium
  • FLUVASTATIN SODIUM
  • FLUVASTATIN LACTONE
  • FLUVASTATIN LACTONE
  • (3R,5S)-Fluvastatin
  • 2-Bromo-6-[4-(methylamino)piperidino]benzonitrile
  • [(2R)-1-(2,2-difluoroethyl)pyrrolidin-2-yl]methanol
  • (1S)-1-(1,2,3,4-tetrahydronaphthalen-1-yl)ethan-1-amine
  • (4-fluorophenyl)(1H-imidazol-2-yl)methanol
  • 2-Amino-6,7-difluorobenzoxazole
  • 3-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)morpholine
  • 4-Bromo-2-{[(4-chlorobenzyl)amino]methyl}phenol
  • 2-methyl-octahydro-1H-isoindol-5-ol
  • 3-(Pyrrolidin-2-yl)-1,2-dihydropyrazin-2-one
  • 5-Hydroxy-2-(trifluoromethyl)benzoic acid
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