Benzocaine

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Names

[ CAS No. ]:
94-09-7

[ Name ]:
Benzocaine

[Synonym ]:
ORTHESIN
Americaine
Ora-jel
ethyl 4-aminobenzene carboxylate
Anaesthesin
AETHOFORM
Benzocainum
Ethyl 4-aminobenzoate
ethyl ester of p-aminobenzoic acid
Benzocaine
Ethoform
4-Aminobenzoic acid ethyl ester
Topcaine
Benzoic acid, 4-amino-, ethyl ester
Solu H
MFCD00007892
Euphagin
EINECS 202-303-5
4-ethoxycarbonylaniline
Norcaine
4-amino-benzoic acid ethyl ester
Norcain
Anaesthin
Anbesol
ethyl 4-amino-benzoate
p-aminobenzoic acid ethyl ester
Ethyl4-aminobenzoate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
310.7±15.0 °C at 760 mmHg

[ Melting Point ]:
88-90 °C

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.189

[ Flash Point ]:
164.2±17.9 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
52.32000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.555

[ Storage condition ]:
0-6°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2450000

CHEMICAL NAME :: Benzoic acid, p-amino-, ethyl ester

CAS REGISTRY NUMBER :: 94-09-7

BEILSTEIN REFERENCE NO. :: 0638434

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: ZR DVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 263,454,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3042 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),34,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),34,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 216 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,900,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,33,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81723 No. of Facilities: 293 (estimated) No. of Industries: 8 No. of Occupations: 7 No. of Employees: 2005 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81723 No. of Facilities: 1499 (estimated) No. of Industries: 12 No. of Occupations: 17 No. of Employees: 167623 (estimated) No. of Female Employees: 146838 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38;R43

[ Safety Phrases ]:
22-24/25-37/39-26-24

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DG2450000

[ Packaging Group ]:
III

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethyl 4-iodobenzoate
Ethanol
4-Aminobenzoic acid
Ethyl 4-nitrobenzoate
4-azido-benzoic acid ethyl ester
Ethyl 4-bromobenzoate
4-allylamino-benzoic acid ethyl ester
Ethyl 4-chlorobenzoate
Ethyl 4-hydrazinobenzoate

DownStream

ethyl 4-[(4-nitrophenyl)methylideneamino]benzoate
4-Hydroxy-2-methyl-quinoline-6-carboxylic acid
ETHYL 4-(TERT-BUTOXYCARBONYLAMINO)BENZOATE
6-Benzothiazolemethanol,2-amino-(9CI)
ethyl 4-phenylsulfanylbenzoate
Sodium 4-aminobenzoate
4-benzamidobenzoic acid
Benzoic acid,4-[(1,3-dioxobutyl)amino]-, ethyl ester
4-(2-oxopyrrolidin-1-yl)benzoic acid
Ethyl 3-bromo-4-cyanobenzoate

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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