Ruxolitinib (INCB018424)

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Names

[ CAS No. ]:
941678-49-5

[ Name ]:
Ruxolitinib (INCB018424)

[Synonym ]:
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-
Ruxolitinib
((3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile)
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile
UNII:82S8X8XX8H
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
INCB018424

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
592.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18N6

[ Molecular Weight ]:
306.365

[ Flash Point ]:
312.2±30.1 °C

[ Exact Mass ]:
306.159302

[ PSA ]:
83.18000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.747

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
  • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
  • (R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
  • (R)-3-cyclopentyl-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
  • INCB032304
  • (2E)-3-Cyclopentylacrylonitrile

DownStream

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate
  • Ruxolitinib phosphate

Related Compounds

  • Ruxolitinib phosphate
  • Ruxolitinib (sulfate)
  • S-Ruxolitinib
  • (Rac)-Ruxolitinib D9
  • (Rac)-Ruxolitinib-d8
  • (3R)-3-(3-oxocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
  • 2-(4-Ethoxyphenyl)-5-(2-methylpropyl)-1,2,3,3a-tetrahydropyrazolo[1,5-a]pyrazin-4-one
  • 6-cyclopropyl-5-fluoro-2-[4-(5-oxo-1-phenylpyrrolidine-3-carbonyl)piperazin-1-yl]-5H-pyrimidin-4-one
  • 3-butyl-1-methyl-4aH-thieno[3,2-d]pyrimidin-1-ium-2,4-dione
  • rac-(3R,4S)-4-[2-(oxolan-2-yl)ethyl]pyrrolidin-3-ol
  • 5,6-Dimethyl-3-[2-oxo-2-[4-(6-oxo-3-phenyldiazinan-4-yl)piperazin-1-yl]ethyl]pyrimidin-4-one
  • [4-(3,5-Dimethylpyrazolidin-4-yl)sulfonyl-1,4-diazepan-1-yl]-(4-phenyloxan-4-yl)methanone
  • 1-Cyclohexyl-4-[[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl]piperazine-2,3-dione
  • 3-[3-[4-(5-Fluoro-4-methyl-6-oxo-1,3-diazinan-2-yl)piperazin-1-yl]-3-oxopropyl]quinazolin-4-one
  • N-[1-(5-fluoro-6-phenylpyrimidin-4-yl)azetidin-3-yl]-N,1-dimethyl-2,6-dioxo-1,3-diazinane-5-carboxamide
  • 6-Cyclopropyl-5-fluoro-2-[4-(9-methylpurin-6-yl)piperazin-1-yl]-1,3-diazinan-4-one
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