Ruxolitinib (INCB018424)

Suppliers

Names

[ CAS No. ]:
941678-49-5

[ Name ]:
Ruxolitinib (INCB018424)

[Synonym ]:
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-
Ruxolitinib
((3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile)
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile
UNII:82S8X8XX8H
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
INCB018424

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
592.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18N6

[ Molecular Weight ]:
306.365

[ Flash Point ]:
312.2±30.1 °C

[ Exact Mass ]:
306.159302

[ PSA ]:
83.18000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.747

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
  • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
  • (R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
  • (R)-3-cyclopentyl-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
  • INCB032304
  • (2E)-3-Cyclopentylacrylonitrile

DownStream

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate
  • Ruxolitinib phosphate

Related Compounds

  • Ruxolitinib phosphate
  • Ruxolitinib (sulfate)
  • S-Ruxolitinib
  • (Rac)-Ruxolitinib D9
  • (Rac)-Ruxolitinib-d8
  • (3R)-3-(3-oxocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
  • [1,1'-Biphenyl]-2-carboxamide, 2'-cyano-N-[4-(2-phenyldiazenyl)phenyl]-
  • (2-Isopentylphenyl)boronic acid
  • alpha-Hydroxy-4-phenoxybenzeneacetonitrile
  • 6-Bromo-1-methyl-2-tetralone
  • [(5-Chloro-2-cyanophenyl)carbamoyl]methyl 2,6-dichloropyridine-4-carboxylate
  • 2-Bromo-N-(2,6-dimethylphenyl)pentanamide
  • 5-(4-Bromophenyl)-2-methyloxazole
  • S-(pyridin-4-yl) (2S,4S)-2-(((benzyloxy)carbonyl)amino)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanethioate
  • 4-(2,3-Dihydro-2-methyl-2-phenyl-1H-inden-1-ylidene)-1-methylpiperidine
  • (2S)-2-{4-[(trifluoromethyl)sulfanyl]phenyl}oxirane
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.