Ruxolitinib (INCB018424)

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Names

[ CAS No. ]:
941678-49-5

[ Name ]:
Ruxolitinib (INCB018424)

[Synonym ]:
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-
Ruxolitinib
((3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile)
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile
UNII:82S8X8XX8H
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
INCB018424

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
592.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18N6

[ Molecular Weight ]:
306.365

[ Flash Point ]:
312.2±30.1 °C

[ Exact Mass ]:
306.159302

[ PSA ]:
83.18000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.747

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
  • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
  • (R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
  • (R)-3-cyclopentyl-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
  • INCB032304
  • (2E)-3-Cyclopentylacrylonitrile

DownStream

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate
  • Ruxolitinib phosphate

Related Compounds

  • Ruxolitinib phosphate
  • Ruxolitinib (sulfate)
  • S-Ruxolitinib
  • (Rac)-Ruxolitinib D9
  • (Rac)-Ruxolitinib-d8
  • (3R)-3-(3-oxocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
  • Ethyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid
  • 4-Pyrimidinecarboxamide,6-(5-methyl-2-furanyl)-n-[[2-(trifluoromethyl)phenyl]methyl]-
  • 4-Pyrimidinecarboxamide,2-amino-6-(4-methyl-2-thiazolyl)-n-[(4-methyl-2-thiazolyl)methyl]-
  • Benzamide,5-chloro-n-[(6-chloro[1,1'-biphenyl]-3-yl)methyl]-2-hydroxy-
  • Benzyl 2-(hydroxymethyl)azepane-1-carboxylate
  • 1-(2-Methyl-4-phenyl-1,3-thiazol-5-yl)ethan-1-one
  • C,C'-Bis-tert-butyl N-4-amino-2-trifluoromethylphenyl)iminodicarbonate
  • 5-Methyl-2-(trifluoromethylthio)chlorobenzene
  • 4-Hydroxy-2-methylisoindoline-1,3-dione
  • 1-(3-(Dimethylamino)propyl)-6-hydroxy-4-methyl-3H-pyridin-2-one
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