Ruxolitinib (INCB018424)

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Names

[ CAS No. ]:
941678-49-5

[ Name ]:
Ruxolitinib (INCB018424)

[Synonym ]:
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-
Ruxolitinib
((3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile)
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile
UNII:82S8X8XX8H
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
INCB018424

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
592.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18N6

[ Molecular Weight ]:
306.365

[ Flash Point ]:
312.2±30.1 °C

[ Exact Mass ]:
306.159302

[ PSA ]:
83.18000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.747

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
  • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
  • (R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
  • (R)-3-cyclopentyl-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
  • INCB032304
  • (2E)-3-Cyclopentylacrylonitrile

DownStream

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate
  • Ruxolitinib phosphate

Related Compounds

  • Ruxolitinib phosphate
  • Ruxolitinib (sulfate)
  • S-Ruxolitinib
  • (Rac)-Ruxolitinib D9
  • (Rac)-Ruxolitinib-d8
  • (3R)-3-(3-oxocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
  • 5-bromo-N-[(2-methoxypyridin-3-yl)methyl]pyridin-2-amine
  • 4-iodo-N-(pyrazin-2-yl)benzamide
  • 2-Oxopropyl 2-acrylamidoacetate
  • TriMan
  • 1-(2-Bromoethyl)-3-(methylsulfanyl)benzene
  • Methyl 5-sulfamoyl-2,3-dihydro-1-benzofuran-3-carboxylate
  • methyl (6-bromo-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate
  • 1-(2-Chloroethyl)-3,5-bis(trifluoromethyl)benzene
  • 1-(2-Bromophenyl)-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid
  • Benzyl 2,2-dimethyl-3-oxopiperazine-1-carboxylate