INCB032304

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Names

[ CAS No. ]:
941685-27-4

[ Name ]:
INCB032304

[Synonym ]:
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
4-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine
4-(1H-Pyrazol-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine
7H-Pyrrolo[2,3-d]pyrimidine, 4-(1H-pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-
4-(1H-PYRAZOL-4-YL)-7-((2-(TRIMETHYLSILYL)ETHOXY)-METHYL)-7H -PYRROLO[2,3-D]PYRIMIDINE
INCB032304

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
501.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H21N5OSi

[ Molecular Weight ]:
315.45

[ Flash Point ]:
257.3±30.1 °C

[ Exact Mass ]:
315.151550

[ PSA ]:
68.62000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.607

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Pyrazole-4-boronic acid pinacol ester
  • 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
  • 1-(1-Ethoxyethyl)-1H-pyrazole-4-boronic acid pinacol ester
  • [2-(Chloromethoxy)ethyl](trimethyl)silane
  • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

DownStream

  • (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate
  • Ruxolitinib (INCB018424)
  • Ruxolitinib phosphate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-Chloro-1-(2-(4-(trifluoromethyl)pyrimidin-2-yl)pyrrolidin-1-yl)propan-1-one
  • 2-Chloro-N-[(3S,4S)-4-(1-ethylpyrazol-4-yl)oxyoxolan-3-yl]propanamide
  • 2-Chloro-N-(5,6-dihydro-4H-benzo[f]imidazo[1,2-a]azepin-4-yl)propanamide
  • 2-[1-(2-Chloropropanoyl)piperidin-3-yl]-5-[methyl(propan-2-yl)amino]pyridazin-3-one
  • 2-Chloro-1-[2-[1-hydroxy-1-(4-methoxyphenyl)ethyl]pyrrolidin-1-yl]propan-1-one
  • 2-Chloro-N-(7-phenylmethoxy-1,4-dioxaspiro[4.5]decan-8-yl)propanamide
  • 2-Chloro-1-[3-fluoro-3-(2-fluorophenyl)azetidin-1-yl]propan-1-one
  • 2-Chloro-N-[1-(1,3-oxazol-2-yl)-2-phenylethyl]propanamide
  • [1-(2-Chloropropanoyl)piperidin-2-yl]methyl 4-methylpiperidine-1-carboxylate
  • 2-chloro-1-[2-(1-ethyl-1H-imidazol-5-yl)piperidin-1-yl]propan-1-one
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