Efortil

Suppliers

Names

[ CAS No. ]:
943-17-9

[ Name ]:
Efortil

[Synonym ]:
etilefrine hydrochloride
Effortil
α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride
N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride
3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
Thomasin
Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1)
Effortil*HCl
EINECS 213-398-8
Etilefrin-HCl
3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1)
Etilefrin dl-form hydrochloride
Cardanat
Etilefrine HCl
Effontil
Efortil
Circupon

Chemical & Physical Properties

[ Density]:
1.127g/cm3

[ Boiling Point ]:
351.7ºC at 760 mmHg

[ Melting Point ]:
122ºC

[ Molecular Formula ]:
C₁₀H₁₆ClNO₂

[ Molecular Weight ]:
217.69

[ Flash Point ]:
155.5ºC

[ Exact Mass ]:
217.086960

[ PSA ]:
52.49000

[ LogP ]:
2.22800

[ Water Solubility ]:
Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO5618000

CHEMICAL NAME :: Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride

CAS REGISTRY NUMBER :: 943-17-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H15-N-O2.Cl-H

MOLECULAR WEIGHT :: 217.72

WISWESSER LINE NOTATION :: QR CYQ1M2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 187 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,187,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,225,1995

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,115,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
DO5618000

[ HS Code ]:
2922509090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Indications, surgical technique, and long-term experience with laparoscopic closure of the nephrosplenic space in standing horses.

Vet. Surg. 34(6) , 637-41, (2005)

To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses.Retros...

[A complicated course after esophagogastrectomy].

J. Chir. (Paris.) 144(3) , 241-5, (2007)

Priapism in a patient with unstable hemoglobin: hemoglobin Köln.

Am. J. Hematol. 74(1) , 73-4, (2003)

We report a case of severe priapism occurring in a patient with unstable hemoglobin, hemoglobin Köln, and underline several factors that may have contributed to this complication: abnormal plasticity ...

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