(E)-3-(4-Methoxyphenyl)acrylic acid

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Names

[ CAS No. ]:
943-89-5

[ Name ]:
(E)-3-(4-Methoxyphenyl)acrylic acid

[Synonym ]:
3-(4-Methoxy-phenyl)-acrylic acid
trans-4-Methoxycinnamic acid
4-MeOC6H4CH=CHCOOH
4-methoxycinnamate
RARECHEM BK HC T257
2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-
2-Propenoic acid, 3- (4-methoxyphenyl)-
(E)-3-(4-methoxyphenyl)acrylic acid
4-Methoxy-(2E)-cinnamic acid
4-Methoxyciamic acid
p-coumaric acid methyl ether
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
UNII-6G4ML8401A
(E)-p-methoxycinnamic acid
4-Methoxycinnamic acid
(2E)-3-(4-Methoxyphenyl)acrylic acid
4-methoxy-(E)-cinnamic acid
EINECS 213-405-4
(E)-3-(4-Methoxyphenyl)acrylate
para-methoxycinnamic acid
PMCA
MFCD00004398
(2E)-3-(4-Methoxyphenyl)-2-propenoic acid
para-methoxycinnamate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
342.6±17.0 °C at 760 mmHg

[ Melting Point ]:
173.5ºC

[ Molecular Formula ]:
C10H10O3

[ Molecular Weight ]:
178.185

[ Flash Point ]:
138.6±14.4 °C

[ Exact Mass ]:
178.062988

[ PSA ]:
46.53000

[ LogP ]:
2.36

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UD3391300

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Bromoanisole
  • Acrylic acid
  • 4-Iodoanisole
  • Carbon dioxide
  • 1,3,2-Dioxaborinane, 2-[(1E)-2-(4-methoxyphenyl)ethenyl]-5,5-dimethyl
  • 4-Methoxybenzenediazonium tetrafluoroborate
  • carbon monoxide
  • 1-(2-bromoethenyl)-4-methoxybenzene
  • 4-Methoxybenzaldehyde
  • acetic acid

DownStream

  • (+/-)-7-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydrocoumarin
  • 1,2,3,4-tetrahydroisoquinolin-7-ol,hydrobromide
  • Yangonin
  • 4-Methoxy-3-nitrobenzoic acid
  • 4-METHOXY-3-NITROCINNAMIC ACID
  • 3-nitro-4-anisaldehyde
  • 1-(4-Methoxyphenyl)-2-nitroethylene
  • 4-Methoxybenzaldehyde
  • p-Anisic acid

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

A practical procedure for the large-scale preparation of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate, a key intermediate for diltiazem.

J. Org. Chem. 67(13) , 4599-601, (2002)

A practical synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), was developed. Treatment of methyl (E)-4-methoxycinnamate 3 with chiral dioxirane, gen...

Enzymatic synthesis of cinnamic acid derivatives.

Biotechnol. Lett. 28(8) , 581-5, (2006)

Using Novozym 435 as catalyst, the syntheses of ethyl ferulate (EF) from ferulic acid (4-hydroxy 3-methoxy cinnamic acid) and ethanol, and octyl methoxycinnamate (OMC) from p-methoxycinnamic acid and ...


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Related Compounds

  • (E)-3-(4-methoxyphenyl)acrylic acid
  • (E)-3-(4-methoxyphenyl)-2-(4-nitrophenyl)propenoic acid
  • (E)-3-(4-trimethylsiloxy-3-methoxyphenyl)acrylic acid trimethylsilyl ester
  • (E)-3-(4-Butoxy-3-methoxyphenyl)acrylic acid
  • (E)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)acrylic acid
  • (E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)acrylic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • ((Chlorocarbonyl)oxy)methyl furan-2-carboxylate
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide