Suc-Leu-Tyr-AMC

Suppliers

Names

[ Name ]:
Suc-Leu-Tyr-AMC

[Synonym ]:
CALPAIN SUBSTRATE II,FLUOROGENIC
N-SUCCINYL-LEU-TYR 4-METHYLCOUMARYL-7-AMIDE
succinyl-leucyl-tyrosyl-4-methyl-7-coumarylamide
N-SUCCINYL-LEU-TYR 7-AMIDO-4-METHYLCOUMARIN
CALPAIN SUBSTRATE I
SUC-LEU-TYR-AMC
SUC-LY-AMC
SUCCINYL-LEU-TYR-AMC
SUC-LEU-TYR-7-AMINO-4-METHYLCOUMARIN
MFCD00057900

Chemical & Physical Properties

[ Density]:
1.324g/cm3

[ Boiling Point ]:
945.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₉H₃₃N₃O₈

[ Molecular Weight ]:
551.58800

[ Flash Point ]:
525.6ºC

[ Exact Mass ]:
551.22700

[ PSA ]:
175.04000

[ LogP ]:
3.72350

[ Index of Refraction ]:
1.611

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

J. Biol. Chem. 259 , 12489, (1984)

Homogeneous porcine calpain (Ca2+-dependent cysteine proteinase) was found to hydrolyze a variety of peptides and synthetic substrates. Leu-Trp-Met-Arg-Phe-Ala, eledoisin-related peptide, alpha-neoend...

Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin.

Biochem. J. 248(2) , 589-94, (1987)

Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin was investigated. Human liver cystatins A and B, human cystatin C, chicken cystatin and rat T-kininog...

Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.

Eur. J. Med. Chem. 82 , 274-80, (2014)

Calpains are intracellular cysteine proteases with important physiological functions. Up- or downregulation of their expression can be responsible for several diseases, therefore specific calpain inhi...

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