4-Chloro-2-Methylaniline

Suppliers

Names

[ CAS No. ]:
95-69-2

[ Name ]:
4-Chloro-2-Methylaniline

[Synonym ]:
4-Chloro-2-methylaniline
fastredtr11
devalredk
Ipsilon
Fast Red TR
4-Chloro-o-toluidine
EINECS 202-441-6
p-chloro-o-methylaniline
BENZENAMINE,4-CHLORO-2-METHYL-
5-chloro-2-amino-toluene
Deval Red TR
1-amino-2-methyl-4-chlorobenzene
N-(4-chloro-2-methylphenyl)picolinamide
2-AMINO-5-CHLOROTOLUENE
MFCD00007842
4-CHLOR-2-METHYLANILIN
2-methyl-4-chloro-aniline
Benzenamine, 4-chloro-2-methyl-
redbasentr
RED TR BASE

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
242.8±20.0 °C at 760 mmHg

[ Melting Point ]:
29 °C

[ Molecular Formula ]:
C7H8ClN

[ Molecular Weight ]:
141.598

[ Flash Point ]:
99.4±0.0 °C

[ Exact Mass ]:
141.034531

[ PSA ]:
26.02000

[ LogP ]:
2.22

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XU5000000
CHEMICAL NAME :
o-Toluidine, 4-chloro-
CAS REGISTRY NUMBER :
95-69-2
BEILSTEIN REFERENCE NO. :
0878505
LAST UPDATED :
199710
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C7-H8-Cl-N
MOLECULAR WEIGHT :
141.61
WISWESSER LINE NOTATION :
ZR DG B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1058 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - nausea or vomiting Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977 *** REVIEWS *** IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,123,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,61,1983 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,123,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (12 mg/m3);Skin;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0066 No. of Facilities: 77 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1397 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0066 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 250 (estimated) No. of Female Employees: 250 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H341-H350-H410

[ Precautionary Statements ]:
P201-P261-P273-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/24/25;R45;R50/53;R68

[ Safety Phrases ]:
S53-S45-S60-S61

[ RIDADR ]:
UN 2239 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XU5000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921430090

Synthetic Route

Precursor & DownStream

Precursor

  • o-Toluidine
  • 4-Chloro-2-methylphenylboronic acid
  • 5-Chloro-2-nitrotoluene
  • O-ACETOTOLUIDIDE
  • Methylmagnesium chloride
  • 4-Chloronitrobenzene
  • 2-Nitrotoluene
  • 2-Methylphenyl azide
  • 4'-chloro-2-formotoluidide
  • Ethanoic anhydride

DownStream

  • 1-Bromo-3-chloro-5-methylbenzene
  • 4-Chloro-2-methyl-benzaldehyde
  • 4-Chloro-2-Methylphenyl Isocyanate
  • 4-Chloro-2-methylbenzonitrile
  • 4-Chloro-2-Methylacetanilide
  • 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide
  • 3-(4-chloro-2-methylanilino)propanenitrile
  • 5-Chloro-2-phenyl-1H-indole
  • 7-bromo-5-chloro-1H-indazole
  • 1-(5-Chloro-1H-indazol-1-yl)ethanone

Customs

[ HS Code ]: 2921430090

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%


Related Compounds

  • 4-chloro-2-methylaniline,hydrochloride
  • 5-[butan-2-yl(chloromethyl)phosphinothioyl]oxy-4-chloro-2-methylaniline
  • 4-Chloro-2-iodo-5-methylaniline
  • 4-Chloro-2-iodo-6-methylaniline
  • 4-Chloro-2-(methoxymethyl)-N-methylaniline
  • 4-chloro-2-methoxy-N-methylaniline
  • 1-(2-Fluoro-4-nitrobenzyl)azetidine
  • 6-tert-Butyl-3-ethylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde
  • (4-Iodo-1-methyl-1H-pyrazol-5-yl)methanamine hydrochloride
  • (1S,5R)-3-[(4-Methoxyphenyl)methyl]-3-azabicyclo[3.1.0]hexan-6-amine;dihydrochloride
  • 4-(tert-Butyl)-2-(piperidin-4-ylmethyl)oxazole dihydrochloride
  • Lithium(1+) ion 2-(4-cyclopropyl-1,3-thiazol-2-yl)acetate
  • 2-(3-Ethynylphenyl)propan-2-amine hydrochloride
  • O-[(2,4-Dinitrophenyl)methyl]hydroxylamine;hydrochloride
  • (4-Chloro-1-methyl-1H-pyrazol-5-yl)methanamine dihydrochloride
  • 3-(2,6-Difluorophenyl)pyrrolidine hydrochloride
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