2-Chloro-4-aminotoluene

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Names

[ CAS No. ]:
95-74-9

[ Name ]:
2-Chloro-4-aminotoluene

[Synonym ]:
4-Amino-2-chlorotoluene
4-methyl-5-chloroaniline
3-chloro-4-methylphenylamine
2B oil
CPT
EINECS 202-446-3
3-CHLORO-P-TOLUIDINE
4-Methyl-3-chloroaniline
2-Chloro-4-Aminotoluene Or O-Chloro-P-Aminotoluene
DKC 1347
MFCD00007773
2-chloro-4-amino-toluene
3-CHLOR-4-METHYLANILIN
2-Chloro-4-aminotoluene
1-Amino-3-chloro-4-methylbenzene
3-Chloro-4-methylanilin
2-CHLORO-4-TOLUIDINE
3-CHLORO-4-METHYLANILINE D
3-cpt
DRC 1339
Benzenamine, 3-chloro-4-methyl-
3-Chloro-4-methylaniline
O-CHLORO-P-TOLUIDINE
drc1347
OCPT
Starlicide
cpt[qr]
3-CHLORO-P-TOLUIDINE (NH2=1)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
243.1±20.0 °C at 760 mmHg

[ Melting Point ]:
25 °C

[ Molecular Formula ]:
C₇H₈ClN

[ Molecular Weight ]:
141.598

[ Flash Point ]:
100.8±21.8 °C

[ Exact Mass ]:
141.034531

[ PSA ]:
26.02000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acids, acid anhydrides, chloroformates, reducing agents.

[ Water Solubility ]:
1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU5111000

CHEMICAL NAME :: p-Toluidine, 3-chloro-

CAS REGISTRY NUMBER :: 95-74-9

BEILSTEIN REFERENCE NO. :: 0636511

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C7-H8-Cl-N

MOLECULAR WEIGHT :: 141.61

WISWESSER LINE NOTATION :: ZR CG D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H315-H317-H319-H410

[ Precautionary Statements ]:
P273-P280-P301 + P310-P305 + P351 + P338-P312-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38;R50/53

[ Safety Phrases ]:
S36/37/39-S45-S61-S60-S36/37-S26

[ RIDADR ]:
UN 2239 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
XU5111000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

CNT
3-Chloro-N-methylaniline
4-Nitrotoluene
1-(Bromomethyl)-2-chloro-4-nitrobenzene
2-Chlorotoluene
2-Amino-4-chloro-5-methylbenzenesulfonic acid
Chlortoluron
Sodium n-propoxide
benzene
Sodium ethoxide

DownStream

2,4-Dichlorobenzoic acid
2-Chloro-4-methoxytoluene
3-Chloro-N-(3-chloro-4-methylphenyl)propanamide
3-Chloro-4-methylbenzoic acid
Ethanone, 1-(2-amino-4-chloro-5-methylphenyl)-2-chloro- (9CI)
2-anilino-4-methoxybenzoic acid
3-chloro-4-methylbenzamide
CB 300919
3-(3-chloro-4-methylphenyl)-5-(prop-2-ynoxymethyl)-1,3-oxazolidin-2-one
tert-butyl 4-(((2-(acetoxyMethyl)-7-chloro-3-Methyl-4-oxo-3,4-dihydroquinazolin-6-yl)Methyl)(prop-2-ynyl)amino)benzoate

Articles

[Method of determining p-nitrotoluene, 2-chloro-4-nitrotoluene and 3-chloro-4-methylaniline in the air].

Gig. Tr. Prof. Zabol. (1) , 43-4, (1980)

Pathological features of 3-chloro-4-methyl benzamine HCl toxicity in rooks (Corvus frugilegus L.) and pheasants (Phasianus colchicus L.).

Gegenbaurs Morphol. Jahrb. 128(5) , 753-61, (1982)

Gross and microscopic changes in response to single po. doses of avicide 3-chloro-4-methyl benzamine HCl were studied in rooks (Corvus frugilegus L.) and pheasants (Phasianus colchicus L.). The observ...

Stabilization of the avicide 3-chloro-p-toluidine as the beta-cyclodextrin adduct.

J. Agric. Food Chem. 47(7) , 2904-7, (1999)

Stabilization of the avicide 3-chloro-p-toluidine (CPTH) on rice baits by pseudo latex polymeric coating and beta-cyclodextin inclusion was investigated. When CPTH-treated rice baits were exposed to s...