Diethyloxalate

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Names

[ CAS No. ]:
95-92-1

[ Name ]:
Diethyloxalate

[Synonym ]:
diethyl ester of oxalic acid
diethyl ethane-1,2-dioate
oxalic diethyl ester
DIETHYL OXALATE FOR PHARMA SYNTHESIS
Oxalic ether
diethyl dicarboxylate
DI ETHYL OXALATE
Ethanedioic acid,diethyl ester
EINECS 202-464-1
ETHYL OXALATE
MFCD00009119
OXALIC ACID DIETHYL ESTER
DIETHYL OXALATE (2.5 LT PVC)
Diethyloxalate
diethyl ethanedioate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
185.4±0.0 °C at 760 mmHg

[ Melting Point ]:
−41 °C(lit.)

[ Molecular Formula ]:
C6H10O4

[ Molecular Weight ]:
146.141

[ Flash Point ]:
75.6±0.0 °C

[ Exact Mass ]:
146.057907

[ PSA ]:
52.60000

[ LogP ]:
0.73

[ Vapour density ]:
5.03 (vs air)

[ Vapour Pressure ]:
0.7±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.411

[ Stability ]:
Stable, but moisture sensitive. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
MAY DECOMPOSE

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RO2800000
CHEMICAL NAME :
Oxalic acid, diethyl ester
CAS REGISTRY NUMBER :
95-92-1
BEILSTEIN REFERENCE NO. :
0606350
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H10-O4
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION :
2OVVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,373,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(5),87,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5432 No. of Facilities: 96 (estimated) No. of Industries: 2 No. of Occupations: 17 No. of Employees: 1483 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H360FD-H371-H372

[ Precautionary Statements ]:
P201-P260-P280-P305 + P351 + P338-P308 + P311-P310

[ Target Organs ]:
Kidney

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
S23

[ RIDADR ]:
UN 2525 6.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
RO2800000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2917119000

Synthetic Route

Precursor & DownStream

Precursor

  • Ethanol
  • N,N'-diacetyloxamide
  • Oxalic acid
  • Diethyl malonate
  • diisopropenyl oxalate
  • oxamide
  • N,N,N',N'-tetramethyloxamide
  • Ethanol solution
  • carbon monoxide
  • Dimethyl oxalate

DownStream

  • diethyl 2-[2-(dibenzylamino)ethyl]-3-oxobutanedioate
  • ethyl 2-(2-benzhydrylidenehydrazinyl)-2-oxoacetate
  • 3,4-dioxo-2,5-diphenylhexanedinitrile
  • AI3-15927
  • octane-2,4,5,7-tetrone
  • diethyl 2,4,6-trioxoheptanedioate
  • 2,4,6,7,9-pentaoxo-decanoic acid ethyl ester
  • Ethyl acetopyruvate
  • ethyl 1H-perimidine-2-carboxylate
  • ETHYL3-TRIFLUOROMETHYLBENZOYLACETATE?

Customs

[ HS Code ]: 2917119000

[ Summary ]:
2917119000 oxalic acid salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis and characterization of Schiff base octaazamacrocyclic complexes and their biological studies.

J. Photochem. Photobiol. B, Biol. 142 , 8-19, (2015)

A condensation reaction between 1,2-diphenylethane-1,2-dione dihydrazone (DPEDDH) and dimethyl or diethyloxalate in methanol resulted in a novel Schiff base octaazamacrocyclic ligand, (L): (6,7,14,15-...

Cerium nitrate: a new topical antiseptic for extensive burns.

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The wounds of 60 burned patients were treated topically with cerium nitrate, which was applied either as a cream or in aqueous solution. Cerium nitrate has a potent antiseptic effect in human burn wou...

Diethyl oxalate as new reagent for spectrophotometric determination of ketosteroids.

Anal. Chem. 42(6) , 560-3, (1970)


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Related Compounds

  • diethyl oxalate
  • thiourea diethyl oxalate complex 2:1
  • N,N-diethylhydroxylamine,oxalic acid
  • 2-(2-chloro-7-methoxycarbazol-9-yl)ethyl-diethylazanium,2-hydroxy-2-oxoacetate
  • 4-(6,11-dihydro-5H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yloxy)-N,N-diethylpentan-1-amine,oxalic acid
  • 2-(3-benzyl-3H-inden-1-yl)-N,N-diethylethanamine,oxalic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-(1-Amino-3-methylcyclohexyl)piperidin-4-ol
  • benzyl N-[1-(dimethylamino)-3-hydroxypropan-2-yl]carbamate
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • Methyl 4-(3-hydroxyoxan-3-yl)thiane-4-carboxylate
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 2-(4-{3-[benzyl(methyl)amino]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido}-1H-pyrazol-1-yl)acetic acid
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide