Adavosertib (MK-1775)

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Names

[ CAS No. ]:
955365-80-7

[ Name ]:
Adavosertib (MK-1775)

[Synonym ]:
2-allyl-1,8-dimethoxy-9,10-anthraquinone
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
2-allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
2-Allyl-1-[6-(2-hydroxy-2-propanyl)-2-pyridinyl]-6-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
9,10-Anthracenedione,1,8-dimethoxy-2-(2-propenyl)
2-allyl-1,8-dimethoxyanthracene-9,10-dione
MK-1775
MK1775
AZD1775

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
723.8±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H32N8O2

[ Molecular Weight ]:
500.595

[ Flash Point ]:
391.5±35.7 °C

[ Exact Mass ]:
500.264832

[ PSA ]:
104.34000

[ LogP ]:
0.50

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.655

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-ALLYL-1-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL)-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3(2H)-ONE
  • 4-(4-Methylpiperazino)aniline

DownStream

Related Compounds

  • Raltegravir (MK-0518)
  • Verlukast
  • (S)-3-(((3-(2-(7-chloroquinolin-2-yl)-(E)-ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propionic acid
  • (+)-MK 801 Maleate
  • Suvorexant(MK-4305)
  • Odanacatib(MK-0822)
  • 2-methyl-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid
  • 3-(2,4-Dimethoxypyridin-3-yl)-2,2-dimethylpropanoic acid
  • 2-[5-(Trifluoromethyl)pyridin-2-yl]cyclopropane-1-carboxylic acid
  • 2-(5-Fluoro-2-hydroxyphenyl)cyclopropane-1-carboxylic acid
  • Lithium(1+)3-methoxy-4-(trifluoromethyl)benzene-1-sulfinate
  • 1-(1-ethyl-1H-pyrazol-3-yl)-3-hydroxycyclobutane-1-carboxylic acid
  • 2-[1-(4-methyl-1H-imidazol-5-yl)cyclopropyl]acetic acid
  • 2-(3-Cyclopropylphenyl)-2,2-difluoroacetic acid
  • 5-[3-(Trifluoromethyl)pyridin-2-yl]-1,2-oxazole-3-carboxylic acid
  • 1-(1-ethyl-1H-pyrazol-3-yl)cyclopentane-1-carboxylic acid
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