GDC-0941

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Names

[ CAS No. ]:
957054-30-7

[ Name ]:
GDC-0941

[Synonym ]:
4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
pictrelisib
Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-
GDC0941
GDC-941
GDC 0941
2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin
2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)-1-piperazinyl]methyl}-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
Pictilisib
2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
GDC-0941
GDC-0941 bismesylate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
687.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H27N7O3S2

[ Molecular Weight ]:
513.636

[ Flash Point ]:
369.7±34.3 °C

[ Exact Mass ]:
513.161682

[ PSA ]:
144.17000

[ LogP ]:
2.04

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.753

Safety Information

[ HS Code ]:
29350090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
  • 4-(2-CHLORO-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE
  • 4-(2-Chlorothieno[3,2-d]pyrimidin-4-yl)morpholine
  • 3-Bromo-2-methylaniline
  • Bis(pinacolato)diboron
  • 4-Bromoindazole
  • Thieno[3,2-d]pyrimidine-2,4-diol
  • Methyl 3-amino-2-thiophenecarboxylate
  • 2,4-Dichlorothieno[3,2-d]pyrimidine
  • 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

DownStream

Related Compounds

  • GDC-0941 (dimethanesulfonate)
  • GDC-0853
  • GDC-2394
  • GDC-0134
  • GDC-0068
  • GDC-0276
  • 6-((1-((3-fluoro-4-methoxyphenyl)sulfonyl)pyrrolidin-3-yl)oxy)-N,N-dimethylpyridazin-3-amine
  • 6-((1-((2,3-dihydrobenzofuran-5-yl)sulfonyl)pyrrolidin-3-yl)oxy)-N,N-dimethylpyridazin-3-amine
  • Methyl 2-(pyrimidin-4-yloxy)acetate
  • 4-((3-((6-(Dimethylamino)pyridazin-3-yl)oxy)pyrrolidin-1-yl)sulfonyl)benzonitrile
  • (E)-3-(furan-2-yl)-1-(3-(pyridazin-3-yloxy)piperidin-1-yl)prop-2-en-1-one
  • 2-(1H-benzo[d]imidazol-1-yl)-1-(3-(pyridazin-3-yloxy)piperidin-1-yl)ethanone
  • 1-methyl-3-(3-(pyridazin-3-yloxy)piperidine-1-carbonyl)pyridin-2(1H)-one
  • (2-Methylthiazol-4-yl)(3-(pyridazin-3-yloxy)piperidin-1-yl)methanone
  • 2-methyl-6-(3-(pyridazin-3-yloxy)piperidine-1-carbonyl)pyridazin-3(2H)-one
  • Benzo[d]thiazol-6-yl(3-(pyridazin-3-yloxy)piperidin-1-yl)methanone
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