2-BUTANONE OXIME
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Names
[ CAS No. ]:
96-29-7
[ Name ]:
2-BUTANONE OXIME
[Synonym ]:
(2E)-N-Hydroxybutan-2-imine
2-BUTANONE OXIME
2-Butanone, oxime, (2E)-
MFCD00013935
EINECS 202-496-6
(2E)-N-Hydroxy-2-butanimine
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
152.5±0.0 °C at 760 mmHg
[ Melting Point ]:
-30 °C
[ Molecular Formula ]:
C4H9NO
[ Molecular Weight ]:
87.120
[ Flash Point ]:
60.0±0.0 °C
[ Exact Mass ]:
87.068413
[ PSA ]:
32.59000
[ LogP ]:
0.65
[ Vapour density ]:
3 (vs air)
[ Vapour Pressure ]:
1.9±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.422
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May react with strong acids to form an explosive material.
[ Water Solubility ]:
114 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL9275000
- CHEMICAL NAME :
- 2-Butanone, oxime
- CAS REGISTRY NUMBER :
- 96-29-7
- BEILSTEIN REFERENCE NO. :
- 1698241
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 24
- MOLECULAR FORMULA :
- C4-H9-N-O
- MOLECULAR WEIGHT :
- 87.14
- WISWESSER LINE NOTATION :
- QNUY2&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 930 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >50 gm/m3/4H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2702 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 200 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6825 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 ppm/6H/4W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1000 ppm/6H/8W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 mL/kg/4W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Endocrine - changes in spleen weight Blood - changes in spleen
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 ppm/6H/4W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 ppm/6H/8W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 ppm/6H/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 4600 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,149,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1326 No. of Facilities: 60 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 180 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82905 No. of Facilities: 1540 (estimated) No. of Industries: 15 No. of Occupations: 36 No. of Employees: 12114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82905 No. of Facilities: 26030 (estimated) No. of Industries: 192 No. of Occupations: 112 No. of Employees: 313185 (estimated) No. of Female Employees: 25609 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H312-H317-H318-H351
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R21;R40;R41;R43
[ Safety Phrases ]:
S13-S23-S26-S36/37/39-S61-S45-S36/37-S25
[ RIDADR ]:
UN 1993 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
EL9275000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
29280090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Toxicol. Sci. 47(2) , 144-50, (1999)
Acetoxime and methylethyl ketoxime (MEKO) are tumorigenic in rodents, inducing liver tumors in male animals. The mechanisms of tumorigenicity for these compounds are not well defined. Oxidation of the...
Dalton Trans. (16) , 3074-84, (2009)
[2 + 3] cycloaddition of the pyrrolin N-oxide (-)O[upper bond 1 start](+)N[double bond, length as m-dash]CHCH(2)CH(2)C[upper bond 1 end]Me(2) with 2-cyanopyridine NC(5)H(4)(2-CN) in the presence of Pd...
Arch. Toxicol. 72(5) , 270-6, (1998)
Both oximes and hydroxylamine (HYAM) are compounds with known oxidative capacity. We tested in vitro whether acetaldoxime (AAO), cyclohexanone oxime (CHO), methyl ethyl ketoxime (MEKO) or HYAM affect ...