trans-4-hydroxy-1-(4-nitrobenzyloxycarbonyl)-l-proline

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Names

[ CAS No. ]:
96034-57-0

[ Name ]:
trans-4-hydroxy-1-(4-nitrobenzyloxycarbonyl)-l-proline

[Synonym ]:
(4R)-4-Hydroxy-1-{[(4-nitrobenzyl)oxy]carbonyl}-L-proline
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-[(4-nitrophenyl)methyl] ester, (2S,4R)-

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
578.3±50.0 °C at 760 mmHg

[ Melting Point ]:
182-183℃

[ Molecular Formula ]:
C13H14N2O7

[ Molecular Weight ]:
310.259

[ Flash Point ]:
303.5±30.1 °C

[ Exact Mass ]:
310.080109

[ PSA ]:
132.89000

[ LogP ]:
-0.37

[ Appearance of Characters ]:
Solid

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.639

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-Hydroxyproline
  • 4-Nitrobenzyl chloroformate
  • (4-Nitrophenyl)methanol

DownStream

  • Meropenem
  • Protected meropenem
  • Side chain for meropenem
  • (2S,TRANS)-4-NITROBENZYL 2-(HYDROXYMETHYL)-4-((METHYLSULFONYL)OXY)PYRROLIDINE-1-CARBOXYLATE
  • (2S,4R)-2-METHYL 1-(4-NITROBENZYL) 4-((METHYLSULFONYL)OXY)PYRROLIDINE-1,2-DICARBOXYLATE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%