10-Ketonaltrexone

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Names

[ Name ]:
10-Ketonaltrexone

[Synonym ]:
(5|A)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6,10-dione
10-Ketonaltrexone
10-oxonaltrexone
Morphinan-6,10-dione,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dih ydroxy-,(5alpha)
Naltrexone Impurity 3

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
633.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₁NO₅

[ Molecular Weight ]:
355.38400

[ Flash Point ]:
337ºC

[ Exact Mass ]:
355.14200

[ PSA ]:
87.07000

[ LogP ]:
1.10350

[ Index of Refraction ]:
1.722

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(4S,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7a-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7,13-dione
Naltrexone 3-Methyl Ether

DownStream

Articles

10-Ketonaltrexone and 10-ketooxymorphone.

J. Med. Chem. 28(7) , 974-6, (1985)

Ethylketocyclazocine (1) has greater kappa/mu selectivity than cyclazocine in brain binding assays. 10-Ketonaltrexone (11) and 10-ketooxymorphone (10) were prepared from naltrexone 3-methyl ether and ...

10-Ketonaltrexone-3-methyl Ether
10-BROMO-2,3-DIMETHYLANTHRACENE
10,11-dehydro-2-acetoxytrimipramine
10-cyclohexyl-10H-anthracen-9-one
10,12-Pentadecadien-1-ol
10-[5-methoxy-1-(4-methoxyphenyl)sulfonylindol-3-yl]decan-1-ol
N-Methyl-1-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)methanamine
methyl 3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylate
Methyl 5-amino-2'-fluoro-[1,1'-biphenyl]-2-carboxylate
3-(1-(3-Fluoro-2-iodophenyl)ethoxy)-5-bromopyridin-2-amine
3-(1-(2-Chloro-3-fluoro-6-iodophenyl)ethoxy)-5-bromopyrazin-2-amine
4-Bromo-5-(3-hydroxypropyl)-N,n,3-trimethyl-1h-pyrazole-1-sulfonamide
Tert-butyl (1-((2-(trimethylsilyl)ethoxy)methyl)-4-bromo-3-cyano-1h-pyrazol-5-yl)methylmethylcarbamate
N-[3-[1-[2-[[[[3-(1,1-dimethylethyl)-1-methyl-1h-pyrazol-5-yl]methyl]methylamino]carbonyl]-3-pyridinyl]ethoxy]-5-iodo-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester
2-(1-Methyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)ethan-1-amine
2-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)ethan-1-amine

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