Nifuroxazide

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Names

[ CAS No. ]:
965-52-6

[ Name ]:
Nifuroxazide

[Synonym ]:
Benzoic acid, 4-hydroxy-, 2-[(1E)-(5-nitro-2-furanyl)methylene]hydrazide
Nifuroxazide
Ercefuryl
Diarlidan
Dicoferin
EINECS 213-522-0
Nifuroxazid
Nifuroxazidum
4-Hydroxy-N'-[(E)-(5-nitro-2-furyl)methylene]benzohydrazide
Nifuroxazida
p-hydroxy-N'-(5-nitrofurfurylidene)benzhydrazide
MFCD00079482
Nifuroxazidum [INN-Latin]
Ercefurol

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
281-283°C

[ Molecular Formula ]:
C12H9N3O5

[ Molecular Weight ]:
275.217

[ Exact Mass ]:
275.054230

[ PSA ]:
120.65000

[ LogP ]:
0.59

[ Index of Refraction ]:
1.653

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2528300
CHEMICAL NAME :
Benzoic acid, p-hydroxy-, (5-nitrofurfurylidene)hydrazide
CAS REGISTRY NUMBER :
965-52-6
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H9-N3-O5
MOLECULAR WEIGHT :
275.24
WISWESSER LINE NOTATION :
T5OJ BNW E1UNMVR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Kidney, Ureter, Bladder - other changes in urine composition

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
250 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,55,1987

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DH2528300

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Nitro-2-furaldehyde diacetate
  • 4-Hydroxybenzhydrazide
  • Methyl 4-hydroxybenzoate
  • 4-Hydroxybenzoic acid

DownStream

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

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Anal. Chim. Acta 862 , 41-52, (2015)

An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran ...

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Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide.

Res. Microbiol. 153(7) , 427-34, (2002)

Two nitrofurans present broad-spectrum antimicrobial properties and some of them are used in human and veterinary medicine. Most of these molecules are mutagens and some of them were reported as carci...


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Related Compounds

  • Nifuroxazide-d4
  • 3-[N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4,4-trifluorobutanamido]-2-methylpropanoic acid
  • 1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]-3-hydroxypyrrolidine-3-carboxylic acid
  • 2-[N-(cyclopropylmethyl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxybutanamido]acetic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 1-methyl-5-nitro-1H-imidazole-4-sulfonyl fluoride
  • 1-(1-Cyanoethyl)cyclopropane-1-sulfonyl chloride
  • 2,2-Dimethyl-1-[2-(propan-2-yl)-1,3-thiazol-4-yl]cyclopropan-1-amine
  • (3R)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1,3-thiazol-5-yl)propanamido]pentanoic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile