5-(N-Methyl-N-isobutyl)-Amiloride

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Names

[ CAS No. ]:
96861-65-3

[ Name ]:
5-(N-Methyl-N-isobutyl)-Amiloride

[Synonym ]:
5-(N-Methyl-N-isobutyl)amiloride
Methylisobutylamiloride
MFCD00078567
Lopac-A-5585
5-Nmnia
3-amino-6-chloro-n-(diaminomethylene)-5-[isobutyl(methyl)amino]pyrazine-2-carboxamide

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Boiling Point ]:
543.9ºC at 760mmHg

[ Melting Point ]:
200-201 °C

[ Molecular Formula ]:
C11H18ClN7O

[ Molecular Weight ]:
299.76000

[ Flash Point ]:
282.8ºC

[ Exact Mass ]:
299.12600

[ PSA ]:
134.01000

[ LogP ]:
2.34230

[ Index of Refraction ]:
1.664

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer.

Int. J. Oncol. 46(4) , 1788-800, (2015)

We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chroma...

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.

Cancer Biol. Ther. 16(3) , 438-49, (2015)

Tumors often contain hypoxic regions resistant to chemo- and radiotherapy. TH-302 (T) is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoram...

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

Nat. Commun. 6 , 6426, (2015)

Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is si...


More Articles

Related Compounds

  • N-[(2Z)-3-(3-butoxyphenyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-(2-chlorophenyl)acetamide
  • 3-(Bromomethyl)-4-nitrophenyl acetate
  • Methyl 2-methoxy-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoate
  • N-[(2-chlorophenyl)methyl]-3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]-N-methylpropanamide
  • 2-(2,4-dichlorophenoxy)-N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]propanamide
  • (2R)-1-methyl-2-phenylaziridine
  • (2Z)-2-[(5-bromo-1-benzofuran-2-yl)methylidene]-7-{[butyl(methyl)amino]methyl}-6-hydroxy-4-methyl-1-benzofuran-3(2H)-one
  • N-[(2Z)-3-(3-bromophenyl)-5,5-dioxidotetrahydrothieno[3,4-d][1,3]thiazol-2(3H)-ylidene]benzamide
  • (2Z)-2-(1,3-benzodioxol-5-ylmethylidene)-6-[(4-methylbenzyl)oxy]-1-benzofuran-3(2H)-one
  • 5-Chloro-I+/--1-naphthalenyl-2-thiophenemethanol
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