IMD 0354

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Names

[ CAS No. ]:
978-62-1

[ Name ]:
IMD 0354

[Synonym ]:
IKK-2 Inhibitor V
IMD-0354

Chemical & Physical Properties

[ Density]:
1.561g/cm3

[ Boiling Point ]:
323.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₈ClF₆NO₂

[ Molecular Weight ]:
383.67300

[ Flash Point ]:
149.2ºC

[ Exact Mass ]:
383.01500

[ PSA ]:
49.33000

[ LogP ]:
5.40850

[ Index of Refraction ]:
1.543

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Solubility: DMSO (5 mg/ml) or Ethanol (1 mg/ml).

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.

Clin. Sci. (Lond.) 129 , 281-90, (2015)

IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central ...

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.

Biochem. Biophys. Res. Commun. 471 , 576-81, (2016)

Activated fibroblasts continue to proliferate at injury sites, leading to progressive muscular fibrosis in Duchenne muscular dystrophy (DMD). TGF-β1 is a dominant profibrotic mediator thought to play ...